Vol 14, No 5 (May 2026): Acta Pharmacologica Sinica

Review Article

A structural overview of G-protein-coupled receptors in neurological disorders   Pages (1077-1102)
Oindrilla Dutta Gupta, Indranil Chakraborty, Kuntal Pal
Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review   Pages (1103-1116)
Zi-xuan Qiu, Ruo-yu Wang, Yi Zhang, Han-bing Huang, Ruo-yu He, Hao Yan, Pei-hua Luo, Bo Yang, Zhi-fei Xu, Qiao-jun He

Article

G protein-dependent dopamine D2 receptor signaling mediates cocaine-primed reinstatement   Pages (1117-1131)
Hai-bo Li, Yong-hui Liu, Hai Liu, Yuan Li, Qiu-min Le, Fei-fei Wang, Lan Ma, Xing Liu
Protopanaxatriol restores cognitive function in okadaic acid-treated mice via direct inhibition of pathological CDK5 activity   Pages (1132-1148)
Ye Peng, Sha-sha Wang, Ke-dao Lai, Jun-rui Ye, Wen-bing He, Xu Yan, Zhao Zhang, Shi-feng Chu, Nai-hong Chen
MicroRNA-129-5p in the mPFC is involved in the chronic mild stress-induced depression-like behaviors in rats   Pages (1149-1161)
Jing-yi Xu, Chen-chen Li, Hao-chen Zhang, Li-jie Guo, Meng-yu Geng, Xiang-jun He, Li-yong Wang, Hui Li, Yong-jun Wang, Zhi-qing David Xu, Yu-tao Yang
Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation   Pages (1162-1175) Open
Han Wu, Wei-tao Jiang, Qiao-yue Zhao, Xin-yue Zhang, Ping Pang, Chun-lei Wang, Zhuo Wang, Ke-ying Lin, Fang-ting Yao, Kun-kun Zou, Yu-ning Zhang, Tian-qi Duo, Feng Zhang, Ling-hua Zeng, Wei Si, Xue Kong, Jing-lun Song, Teng-fei Pan, Hong-tao Diao, Bao-feng Yang, Yu Bian
Morchella polysaccharide ameliorates myocardial infarction inflammation in mice through increasing gut microbiota-derived 12-HEPE   Pages (1176-1190)
Hui-min Su, Jia-xin Li, Jun-fang Wu, Chao Wu, Shi-hao Sheng, Rui-si Wang, Zhi-qing Guo, Shi-chun Shen, Yun-fei Gao, Bei-duo Tian, Dan-dan Wang, Ping-ping Wu, Ze-qun Yin, Ji-e Yang, Ya-jun Duan, Jun-bo Ge, Shuang Zhang, Li-kun Ma
PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations   Pages (1191-1203)
Zi-yang Chen, Ren Guo, Min Wang, Si-jia Ji, Jing-wei Zhang, Hui-xiang Zheng, Shi-tong Wang, Xin Xie
UBC9-mediated p53 SUMOylation drives tubular senescence and exacerbates acute kidney injury in mice   Pages (1204-1218)
Qi-mei Wu, Jing Liu, Ying-song Mu, Juan Li, Ying-jie Tian, Zhi Wang, Miao Deng, Yang-mei Qiu, Shu Zhou, Zi-yang Zhang, Xin-mei Xu, Liang Ma, Ping Fu, Xiao-yong Yan, Zhou-ke Tan
PPARβ/δ contributes to the antidiabetic effect and the increase in GDF15 caused by metformin   Pages (1219-1232)
Javier Jurado-Aguilar, Emma Barroso, Patricia Rada, Mona Peyman, Adel Rostami, Jesús Balsinde, Ángela M. Valverde, Walter Wahli, Xavier Palomer, Manuel Vázquez-Carrera
A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3   Pages (1233-1248)
Shuo Li, Bing Xu, Ming-jun Lu, Qian-wen Wu, Wen-qing Qin, Zi-qi Dai, Xiao-jiao-yang Li, Jin-zhao Bai, Hai-min Lei, Run-ping Liu
A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting   Pages (1249-1269)
Wen-bin Pei, Zi-yu Lei, Fu-quan Xie, Peng Chen, Yong-cheng Su, Yu-shan Qin, Jiang-quan Li, Qian-wen Shen, Miao-miao Ma, Chun-yi Gao, Jia-chen Zhu, Ya-jie Xu, Kai-yue Zhang, Wen-qing Zhang, Yan-dong Zhang, Tian-hui Hu, Bei-bei Xu
Secoemestrin C exerts rapid and prominent anti-breast cancer effect in triple-negative breast cancer by inducing SLX4 and YAP degradation   Pages (1270-1284)
Xiao-jun Zhao, Yang Xu, Cong-hui Zhang, Cong Zhao, Li Liu, Xiao-wei Wang, Meng-yan Wang, Zi-xiang Gao, Rong-guang Shao, Li-qiang Qi, Yong-sheng Che, Wu-li Zhao
Discovery of a potent and orally bioavailable type Ⅰ PRMTs inhibitor for triple-negative breast cancer treatment   Pages (1285-1299)
Shu-yan Zhou, Qiang-sheng Zhang, Lu Li, Zhi-hao Liu, Xiang Hu, Xue-ying Chen, Xiao Li, Zhan-zhan Feng, Guo-quan Wan, Luo-ting Yu
Targeting RSK2 enhances the efficacy of IGF1R inhibitor against triple-negative breast cancer via antagonizing IGF1/IGF1R signaling mediated by GATA3-IGFBP5 pathway   Pages (1300-1311)
Tian-jiao Shan, Lan-ya Li, Xiao-ya Wan, Yi-zhi Li, Ting Jiang, Zong-lin Chen, Xiao-hui Yu, Yan Cheng
Targeting intrinsic and CAF-mediated signaling by PI3Kα inhibitor CYH33 attenuated metastasis in lung squamous cell carcinoma   Pages (1312-1325)
Xiao-yu Ma, Jie-ting Deng, Zhe-rui Cao, Lan Xu, Jian Ding, Ling-hua Meng
Human germline-like monoclonal antibody against 5T4 enables potent ADC and CAR-T therapies for solid tumors   Pages (1326-1337)
Yi-qing Jiang, Xiao-jie Ma, Yin-man Wang, Yi Feng, Yu Kong, Ai-ling Huang, Zi-xuan Jin, Tian-lei Ying, Yan-ling Wu
Clozapine impaired the hypoglycemic effect of metformin by inhibiting hepatic organic cation transporter 1 (OCT1)   Pages (1338-1350)
Wen-han Wu, Yi-dong Dai, Wen-ke Feng, Hao-ran Chen, Xin-yue Zhu, Ling Jiang, Xiao-dong Liu, Li Liu
Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target   Pages (1351-1360)
Zi-ning Zhu, Chong-zhao You, Qing-ning Yuan, Jiu-yin Xu, Zong-yue Gu, Zheng Huang, Miao Liu, Bei Shan, James Jiqi Wang, Wen Hu, Kai Wang, Wan-chao Yin, You-wei Xu, H. Eric Xu, Can-rong Wu
AI and experimental convergence: a synergistic pathway to JAK2 inhibitor discovery   Pages (1361-1373) Open
Maryam, Hwangeui Cho, Ankit Pokhrel, Sourav Ch, ra, Han-Jung Chae, Kil To Chong, Hilal Tayara
Benchmarking co-folding methods to predict the structures of covalent protein–ligand complexes   Pages (1374-1384)
Tong-han Zhang, Jin-tao Zhu, Zhi-xian Huang, Juan Xie, Jian-feng Pei, Lu-hua Lai