Vol 47, No 4 (April 2026): Acta Pharmacologica Sinica

Review Article

GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction   Pages (791-800) Open
Poojashree B. Chettiar, Shashank M. Dravid
Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression   Pages (801-810)
Ling-zhi Wang, Tao-yu Yang, Zi-hui Xiong, Jian-xin Peng, Jia-wang Zhou, Hong-sheng Wang, Jun-ming He

Article

Serotonin receptor 4 in the ventral CA3 regulates agomelatine- induced anxiolytic-like behaviors   Pages (811-826)
Xiang-hu Liu, Muhammad Naveed, Xiao-yun Hu, Lin-lin Zhu, Fan Meng, Qi-gang Zhou, Jing Zhang
Adapter protein 2-modulated μ-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice   Pages (827-835)
Yu-jie Li, Ruo-song Chen, Gui-ying Zan, Ying-cai Song, Xue-ying Huang, Bing Zhang, Wei-jia Du, Ti-fei Yuan, Zhi-qiang Liu
Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1−/−SNCAA53T double mutant mouse model of Parkinson’s disease   Pages (836-859) Open
Luisa Franck, Lucie Valek, Lisa Hahnefeld, Sandra Trautmann, Carlo Angioni, Marc-Philipp Weyer, Dominique Thomas, Robert Gurke, Ilka Wittig, Gerd Geisslinger, Irmgard Tegeder
NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway   Pages (860-875)
Lei-lei Chen, Qing-qing Shen, Li-ping Sun, Yu-xiang Song, Wen-ting Jia, Le Qu, Jun-xia Xie
Sophocarpine alleviates chronic itch in mouse atopic dermatitis by inhibiting spinal astrocyte reactivity and pro-inflammatory signaling   Pages (876-887)
Meng-ping Lou, Xin-yi Gao, He-ting Yan, Teng Lin, Hua Zhai, Long-zhen Wang, Jia-ning Li, Yi-xin Wang, Ruo-fan Zhang, Yan-qing Wang, Wen-li Mi
Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway   Pages (888-902)
Xiao-yu Wang, Wen-shu Zhou, Uma Gaur, Xue-chu Zhen, Wen-hua Zheng
β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke   Pages (903-916)
Ming-jia Yu, Rui-qi Xiong, Jing-wen Wu, Yong-chuan Li, Jia-xin Xie, Hai-ping Zhou, Guan-yu Ye, Yuan Chang, Kai-bin Huang, Su-yue Pan
Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway   Pages (917-931)
Meng-ying Feng, Yan-song Tang, Su Yao, Hong-jie Zhang, Bi-lin Liu, Rong-rong Huang, Shi-qi Huang, Zhao-hui Ou-yang, Min Yuan, Rui Jiang, Da-chun Xu, Guo-hua Gong, Ke Wei
Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD   Pages (932-945)
Xiao-min Zhang, Jing-ya Gao, Dong Wang, Xiang Wei, Li Lin, Xin-rui Xie, Han Gao, Xiu-yun Wang, Hong-ting Hua, Yong-xia Xu, Lei Zhang, Chao-bing Gao, Hua-bing Zhang
β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by targeting the RAC1/mTOR/TFEB axis thus activating lipophagy-lysosomal pathway   Pages (946-963)
Yang Wang, Yi Sun, Chang-yuan Wang, Min Cao, Ru Hao, Shan Wang, Hui-jun Sun
A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts   Pages (964-976)
Hong-yan Qian, Yan He, Chao-qiong Deng, Ao-di Wang, Yong-xin Ma, Hong-jun Zhuang, Shi-peng Chen, Yan Li, Shi-ju Chen, Xin-wei Zhang, Nasrullah Jan, Gui-xiu Shi, Yuan Liu
Graph-based deep learning approach for high-throughput protein-DNA interaction scoring   Pages (977-989)
Yi-hao Zhao, Ying Wang, Chao Shen, De-jun Jiang, Shu-kai Gu, Hui-feng Zhao, Zi-yi You, Ting-jun Hou, Yu Kang
Discovery of a novel Nav1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays   Pages (990-998)
Ying-ying Wang, Gao-ang Wang, Qing You, Yi-fei Liu, Wang-lin Qu, Yi-hong Chen, Chen-zhang Mu, Xi Zhou, Min Liu, Wei Yang, Ting-jun Hou
Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase   Pages (999-1014) Open
Lei Gong, Chang-xiao-feng Liu, Jian-hua Cheng, Jing Guo, Bin Li, Hong-yun Wang, Meng Liu, Jia-lin Wang, Xue-jing Li, Qiu-yue Fang, Zhao-yi Yi, Chu-zhong Li, Ya-zhuo Zhang, Wei-yan Xie
MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer   Pages (1015-1028)
Jin-jin Peng, Min Shao, Yu-yi Li, Jing Feng, Xin-tian Zhang, Che Xu, Qing-xin Xie, Wang-shuang Chen, Jia-qing Chen, Di Wu, Fang Bai, Han Yao, Yu-dao Shen, Xiang-jun Meng
ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway   Pages (1029-1041)
Ming-yang Qin, Yuan-hui Liu, Ze-liang Wu, Yi Huang, Jiang Wang, Tian Xia, Lin Zhu, Hui Liu, Rong Xu
LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation   Pages (1042-1057)
Fei-fei Xu, Hui-min Sun, Yuan Liu, Kai Ye, Zhi-yu Liu, Xue-li Fu, Zhi-tu Zhu, Wei-ying Zhang, Li-hong Ye
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis   Pages (1058-1069)
Christian D. Mitchell, Carol A. Morris, Melissa Wild, Ashlynn Cunningham, Piyanan Chuesiang, Aya A. Mohammed, Bolni Marius Nagalo, Nancy J. Rusch, Abdelrahman Y. Fouda, Esraa Shosha

Correction

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating   Pages (1074)
Yuan-ping Dong, Yun Wu, Yi-lu Zhao, Yu-min Chen, Tong-ye Liu, Yi-he Zhang, Jie-ying Xie, Jin-feng Zhang, Han Zhang, He Chen, Yu Peng, Chun-lei Zhang, Andrew R. Rau, Kasper B. Hansen, Hai-bing Xu, Feng Yi
Correction: TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation   Pages (1075-1076)
Lian-pan Wu, Zheng-fan Gong, He Wang, Zhong-shu Zhou, Ming-ming Zhang, Chao Liu, Hong-mei Ren, Jian Yang, Yu Han, Chun-yu Zeng