Vol 47, No 4 (April 2026) - Acta Pharmacologica Sinica

Review Article

GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction Pages (791-800) Open

Poojashree B. Chettiar, Shashank M. Dravid

Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression Pages (801-810)

Ling-zhi Wang, Tao-yu Yang, Zi-hui Xiong, Jian-xin Peng, Jia-wang Zhou, Hong-sheng Wang, Jun-ming He

Article

Serotonin receptor 4 in the ventral CA3 regulates agomelatine- induced anxiolytic-like behaviors Pages (811-826)

Xiang-hu Liu, Muhammad Naveed, Xiao-yun Hu, Lin-lin Zhu, Fan Meng, Qi-gang Zhou, Jing Zhang

Adapter protein 2-modulated μ-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice Pages (827-835)

Yu-jie Li, Ruo-song Chen, Gui-ying Zan, Ying-cai Song, Xue-ying Huang, Bing Zhang, Wei-jia Du, Ti-fei Yuan, Zhi-qiang Liu

Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1^−/−SNCA^A53T double mutant mouse model of Parkinson’s disease Pages (836-859) Open

Luisa Franck, Lucie Valek, Lisa Hahnefeld, Sandra Trautmann, Carlo Angioni, Marc-Philipp Weyer, Dominique Thomas, Robert Gurke, Ilka Wittig, Gerd Geisslinger, Irmgard Tegeder

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway Pages (860-875)

Lei-lei Chen, Qing-qing Shen, Li-ping Sun, Yu-xiang Song, Wen-ting Jia, Le Qu, Jun-xia Xie

Sophocarpine alleviates chronic itch in mouse atopic dermatitis by inhibiting spinal astrocyte reactivity and pro-inflammatory signaling Pages (876-887)

Meng-ping Lou, Xin-yi Gao, He-ting Yan, Teng Lin, Hua Zhai, Long-zhen Wang, Jia-ning Li, Yi-xin Wang, Ruo-fan Zhang, Yan-qing Wang, Wen-li Mi

Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway Pages (888-902)

Xiao-yu Wang, Wen-shu Zhou, Uma Gaur, Xue-chu Zhen, Wen-hua Zheng

β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke Pages (903-916)

Ming-jia Yu, Rui-qi Xiong, Jing-wen Wu, Yong-chuan Li, Jia-xin Xie, Hai-ping Zhou, Guan-yu Ye, Yuan Chang, Kai-bin Huang, Su-yue Pan

Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway Pages (917-931)

Meng-ying Feng, Yan-song Tang, Su Yao, Hong-jie Zhang, Bi-lin Liu, Rong-rong Huang, Shi-qi Huang, Zhao-hui Ou-yang, Min Yuan, Rui Jiang, Da-chun Xu, Guo-hua Gong, Ke Wei

Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD Pages (932-945)

Xiao-min Zhang, Jing-ya Gao, Dong Wang, Xiang Wei, Li Lin, Xin-rui Xie, Han Gao, Xiu-yun Wang, Hong-ting Hua, Yong-xia Xu, Lei Zhang, Chao-bing Gao, Hua-bing Zhang

β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by targeting the RAC1/mTOR/TFEB axis thus activating lipophagy-lysosomal pathway Pages (946-963)

Yang Wang, Yi Sun, Chang-yuan Wang, Min Cao, Ru Hao, Shan Wang, Hui-jun Sun

A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts Pages (964-976)

Hong-yan Qian, Yan He, Chao-qiong Deng, Ao-di Wang, Yong-xin Ma, Hong-jun Zhuang, Shi-peng Chen, Yan Li, Shi-ju Chen, Xin-wei Zhang, Nasrullah Jan, Gui-xiu Shi, Yuan Liu

Graph-based deep learning approach for high-throughput protein-DNA interaction scoring Pages (977-989)

Yi-hao Zhao, Ying Wang, Chao Shen, De-jun Jiang, Shu-kai Gu, Hui-feng Zhao, Zi-yi You, Ting-jun Hou, Yu Kang

Discovery of a novel Na_v1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays Pages (990-998)

Ying-ying Wang, Gao-ang Wang, Qing You, Yi-fei Liu, Wang-lin Qu, Yi-hong Chen, Chen-zhang Mu, Xi Zhou, Min Liu, Wei Yang, Ting-jun Hou

Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase Pages (999-1014) Open

Lei Gong, Chang-xiao-feng Liu, Jian-hua Cheng, Jing Guo, Bin Li, Hong-yun Wang, Meng Liu, Jia-lin Wang, Xue-jing Li, Qiu-yue Fang, Zhao-yi Yi, Chu-zhong Li, Ya-zhuo Zhang, Wei-yan Xie

MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer Pages (1015-1028)

Jin-jin Peng, Min Shao, Yu-yi Li, Jing Feng, Xin-tian Zhang, Che Xu, Qing-xin Xie, Wang-shuang Chen, Jia-qing Chen, Di Wu, Fang Bai, Han Yao, Yu-dao Shen, Xiang-jun Meng

ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway Pages (1029-1041)

Ming-yang Qin, Yuan-hui Liu, Ze-liang Wu, Yi Huang, Jiang Wang, Tian Xia, Lin Zhu, Hui Liu, Rong Xu

LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation Pages (1042-1057)

Fei-fei Xu, Hui-min Sun, Yuan Liu, Kai Ye, Zhi-yu Liu, Xue-li Fu, Zhi-tu Zhu, Wei-ying Zhang, Li-hong Ye

HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis Pages (1058-1069)

Christian D. Mitchell, Carol A. Morris, Melissa Wild, Ashlynn Cunningham, Piyanan Chuesiang, Aya A. Mohammed, Bolni Marius Nagalo, Nancy J. Rusch, Abdelrahman Y. Fouda, Esraa Shosha

Correspondence

Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction- associated steatohepatitis (MASH): a transcriptomic profiling study Pages (1070-1073)

Chen-yang He, Zhi-hua Wang, Jian-ping Weng, Hans Strijdom, Suo-wen Xu

Correction

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating Pages (1074)

Yuan-ping Dong, Yun Wu, Yi-lu Zhao, Yu-min Chen, Tong-ye Liu, Yi-he Zhang, Jie-ying Xie, Jin-feng Zhang, Han Zhang, He Chen, Yu Peng, Chun-lei Zhang, Andrew R. Rau, Kasper B. Hansen, Hai-bing Xu, Feng Yi

Correction: TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation Pages (1075-1076)

Lian-pan Wu, Zheng-fan Gong, He Wang, Zhong-shu Zhou, Ming-ming Zhang, Chao Liu, Hong-mei Ren, Jian Yang, Yu Han, Chun-yu Zeng

Vol 47, No 4 (April 2026): Acta Pharmacologica Sinica

Review Article

GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction Pages (791-800) Open

Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression Pages (801-810)

Article

Serotonin receptor 4 in the ventral CA3 regulates agomelatine- induced anxiolytic-like behaviors Pages (811-826)

Adapter protein 2-modulated μ-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice Pages (827-835)

Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1^−/−SNCA^A53T double mutant mouse model of Parkinson’s disease Pages (836-859) Open

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway Pages (860-875)

Sophocarpine alleviates chronic itch in mouse atopic dermatitis by inhibiting spinal astrocyte reactivity and pro-inflammatory signaling Pages (876-887)

Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway Pages (888-902)

β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke Pages (903-916)

Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway Pages (917-931)

Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD Pages (932-945)

β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by targeting the RAC1/mTOR/TFEB axis thus activating lipophagy-lysosomal pathway Pages (946-963)

A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts Pages (964-976)

Graph-based deep learning approach for high-throughput protein-DNA interaction scoring Pages (977-989)

Discovery of a novel Na_v1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays Pages (990-998)

Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase Pages (999-1014) Open

MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer Pages (1015-1028)

ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway Pages (1029-1041)

LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation Pages (1042-1057)

HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis Pages (1058-1069)

Correspondence

Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction- associated steatohepatitis (MASH): a transcriptomic profiling study Pages (1070-1073)

Correction

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating Pages (1074)

Correction: TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation Pages (1075-1076)

Table of Contents

Cover Image

Vol 47, No 4 (April 2026): Acta Pharmacologica Sinica

Review Article

GluD1 at the synaptic crossroads: from domain structure to circuit dysfunction Pages (791-800) Open

Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression Pages (801-810)

Article

Serotonin receptor 4 in the ventral CA3 regulates agomelatine- induced anxiolytic-like behaviors Pages (811-826)

Adapter protein 2-modulated μ-opioid receptor trafficking in paraventricular thalamus contributes to fentanyl contextual addiction memory in mice Pages (827-835)

Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1−/−SNCAA53T double mutant mouse model of Parkinson’s disease Pages (836-859) Open

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson’s disease through SATB1/DNA damage/p21 signaling pathway Pages (860-875)

Sophocarpine alleviates chronic itch in mouse atopic dermatitis by inhibiting spinal astrocyte reactivity and pro-inflammatory signaling Pages (876-887)

Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway Pages (888-902)

β-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke Pages (903-916)

Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating the canonical Wnt signaling pathway Pages (917-931)

Mup3 ameliorates the dysregulation of glucose and lipid metabolism in MAFLD Pages (932-945)

β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by targeting the RAC1/mTOR/TFEB axis thus activating lipophagy-lysosomal pathway Pages (946-963)

A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts Pages (964-976)

Graph-based deep learning approach for high-throughput protein-DNA interaction scoring Pages (977-989)

Discovery of a novel Nav1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays Pages (990-998)

Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase Pages (999-1014) Open

MS1-96 induces HIP1R-dependent PD-L1 degradation and promotes antitumor immunity in colorectal cancer Pages (1015-1028)

ATM promotes bone metastatic propensity of breast cancer by inducing osteoclastogenesis via the NFκB-CCL2 pathway Pages (1029-1041)

LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation Pages (1042-1057)

HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis Pages (1058-1069)

Correspondence

Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction- associated steatohepatitis (MASH): a transcriptomic profiling study Pages (1070-1073)

Correction

Correction: GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gating Pages (1074)

Correction: TSPO ligands prevent the proliferation of vascular smooth muscle cells and attenuate neointima formation through AMPK activation Pages (1075-1076)

Table of Contents

Cover Image

Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1^−/−SNCA^A53T double mutant mouse model of Parkinson’s disease Pages (836-859) Open

Discovery of a novel Na_v1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays Pages (990-998)