Vol 47, No 3 (March 2026): Acta Pharmacologica Sinica

Review Article

Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke   Pages (549-565)
Long-rui Wang, Zi-yuan Zhao, Zhao-wei Li, Yin-ru Jiang, Wen-jing Sun, Guan-hua Du, Rui-li Shi, Ling-lei Kong
Targeting virus-interacting host ion channels as a novel antiviral strategy   Pages (566-575)
Yu-yao Guo, Xiao-yi Mo, Jia-jing Wu, Chang Xie, Jing Yao

Article

Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis   Pages (576-592)
Yao Chen, Wen-qing Shi, Pei Zhang, Ran Wang, Wen-bo Ye, Guo-qiang Lin, Shou-jiao Peng, Jian-ge Zhang
Esflurbiprofen exerts a fast-onset antidepressant effect by blocking SERT-nNOS interaction   Pages (593-607)
Yu-qi Chen, Jun-rui Ye, Sha-sha Wang, Ye Peng, Run Zhou, Ruo-lan Yuan, Wen-fei Wang, Shi-feng Chu, Zhao Zhang, Nai-hong Chen
Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis   Pages (608-624)
Yan-li Zhang, Shi-xin Ding, Min Cao, Shu-ying Zhang, Yue Li, Ze Wang, Yu-xi Jin, Si-jia Chen, Yi-miao Wang, Charles Marshall, Jing-ping Shi, Jun-ying Gao, Wei-xi Feng, Yin Cao, Ming Xiao, Gang Hu
The mGluR2/3 agonist xanthurenic acid improves memory, attention, and synaptic deficits by modulating glutamate release in Alzheimer’s disease model   Pages (625-635) Open
Kyonghwan Choe, Jawad Ali, Hyun Young Park, Si Hoon Jang, Eun Yeong Choi, Min Hwa Kang, Tae Ju Park, Myeong Ok Kim
Galangin 3-methyl ether alleviates mouse hypertrophic cardiomyopathy via targeting HDAC2 and subsequently inactivating the PI3K-AKT signaling pathway   Pages (636-651) Open
Ke Zhang, Tao Xu, Xin-yu Heng, Jian-zhen Lei, De-shen Han, Shao-hong Huang, Mei-qi He, Lin Pu, Yue-yue Wu, Ning Sun, Hai Yang, Chao Ye
ROS-induced degradation of hERG potassium channels contributes to aripiprazole-induced prolongation of the QTc interval   Pages (652-665)
Yu-hong Cao, Xiao-chen Wang, Hong-kun Wang, Zong-kuai Yang, Dan-dan Liu, Yang Yang, Rong Kuang, Ping Liang
Targeting the 5-HT1B-YAP positive feedback loop protects against disturbed flow-induced atherogenesis in mice   Pages (666-676)
Min-chun Jiang, Huan-yu Ding, Chak Kwong Cheng, Dong-qin Cai, Hai-xia Guan, Jian Kuang, Ronald Ching Wan Ma, Yin Xia, Xiao-qiang Yao, Li Wang, Yu Huang
Formyl peptide receptor 2 is a potential biomarker and therapeutic target for inflammatory bowel disease   Pages (677-688)
Wen-sheng Yang, Xiao-zhen Wang, Wei Wu, Yuan Li, Guang-fei Wang, Qing-tong Zhou, Ming-Wei Wang, Zhi-ping Li
Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease   Pages (689-700)
Dan-dan Zhong, Cheng Hu, Lan-lan Zhao, Yan Shen, Ru-meng Zhang, Ying Liu, Bu-hui Liu, Wen Su, Bao-xue Yang, Hui Xiong, Dong Guo, Dong Sun, Ying-ying Zou, Ying Sun
HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models   Pages (701-713)
Wen-xin Zhang, Ting He, Kun Fang, Ying-lei Gao, Yi-ming Sun, Fa-jun Nan, Jian Ding, Yi Chen, Yan-fen Fang
An engineered IL-21 variant is a potent antitumor candidate for antitumor immunotherapy   Pages (714-722)
Hui Wu, Ya-ping Cheng, Yu-long Liu, Ruo-han Zhu, Li-wen Ji, Ming-kai Wang, Quan-xiao Li, Zhao-ling Shen, Tian-lei Ying, Yan-ling Wu
Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects   Pages (723-734)
Man Zhao, Zu-yi Jin, Wei-zhen Fan, Peng-fei Qiang, Zhi-hua Zheng, Guo-feng Li, Liang Hong, Min Li
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis   Pages (735-749)
Jue Wang, Wei-wei Liu, Qiong-lian Huang, Han-juan Ning, Jian-yi Wang, Xiang-hui Han
Sino-C, a novel sinomenine derivative, induces cell death by disrupting cholesterol homeostasis in colorectal cancer cells   Pages (750-761)
Yan-ming Zhang, Hui Lu, Bing-jie Xiao, Chun-cao Xu, Fan-fan Zhou, Ting Li, Zha-jun Zhan, Jin-jian Lu
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway   Pages (762-775)
Qing Wu, Qi Su, Man Zhu, Tian-feng Yang, Wen-juan Tang, Yu Hu, Jia-yan Ren, Xiu-hong Peng, Su-yu Zhang, Yan-min Zhang
Structure-activity relationship of prevalent synthetic cannabinoid metabolites on hCB1 in vitro and in silico dynamics   Pages (776-789) Open
Anna Åstrand, Emiliano Laudadio, Prince S. Gameli, Laura Martin, Jeremy Carlier, Francesco P. Busardò, Johan Dahlén, Xiongyu Wu, Peter Konradsson, Svante Vikingsson, Robert Kronstrand, Henrik Gréen

Retraction Note

Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2   Pages (790)
Yan-tao Han, Xue-hong Chen, Hui Gao, Jun-li Ye, Chun-bo Wang