Vol 47, No 2 (February 2026): Acta Pharmacologica Sinica

Review Article

Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair   Pages (273-289)
Hui Guo, Wen-cao Liu, Yan-yun Sun, Xin-chun Jin, Pan-pan Geng

Article

Selective recognition memory impairment in mitochondrial hydroxylase Clk1 mutant mice, rescued by antipsychotics   Pages (290-302)
Zhi-feng Shi, Zhe-xiang Yu, Ling-han Gu, Zhi-xue Ma, Qin-bo Chen, Li-bin Wen, John L. Waddington, Xue-chu Zhen
Galangin, a novel Kv7 potassium channel opener, exerts potent antinociceptive effects in multiple chronic pain mouse models   Pages (303-314)
Bo Yang, Hui Liu, Wen-jing Zhao, Jia-rui Ma, Zi-shuo Kang, Yu-jie Zhang, Yu-lin Gu, Xiao-ke Li, Zeng-wei Mao, Rui-feng Cao, Ya-ling Wang, Han Li, Fan Zhang
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction   Pages (315-327)
Cheng-hu Guo, Qian-qian Wang, Jia-qi Li, Wei Ji, Lin Chen, Mei-ling Chang, Lian-yue Ma, Xiao-ling Liu, Mei Ni
Fumarate hydratase ameliorates pressure overload induced cardiac remodeling by controlling Elovl7-mediated biosynthesis of unsaturated fatty acids   Pages (328-343)
Lan-lan Li, Chao-jun Sun, Xiao-tong Mo, Yun Xing, Tong Zhang, Heng Zhang, Nan Zhao, Xiao-feng Zeng, Sha-sha Wang, Yan-yan Meng, Sai-yang Xie, Wei Deng
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation   Pages (344-356)
Hai-bi Su, Jing-huan Wang, Yu-yu Zhang, Jie Xu, Jia-yao Liu, Yu-hui Li, Chen-xi Xiao, Cai-yun Wang, Jun Chang, Xin-hua Liu
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis   Pages (357-369)
Hao Chen, Lin Yang, Xiao-feng Li, Si-yuan Han, Qi Zhao, Rong-cheng Xiao, Zi-yao Ou, Ling Fang, Yan Du
PXR ribosylation at E194 amplifies NAPQI in acetaminophen‒induced liver injury in mice, rescued by Schisandrin B   Pages (370-382)
Jia-chan Long, Chen-xu Liu, Meng-yao Wang, Cai-hong Liu, Fan Zhang, Zhong-qiu Liu, Lin An, Cai-yan Wang
A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis   Pages (383-390)
Hao Zhang, Ya-nan Huo, Ya-wei Zhang, Zhi-feng Cheng, Xiao-jing Wang, Jun Chen, Qi-fu Li, Xin-hua Xiao, Li-zhen Lan, Xin-long Ma, Liu-jun Fu, Xiao-pan Chen, Ling-qing Yuan, Fang-jiang Xu, Li You, Jin- luo Cheng, Dun Hong, Fei Hua, Li Mao, Guo-xi Jin, Guan-feng Yao, Ya-jun Bing, Gui-jie Xie, Ying Yang, Jin Xu, Ying Zhang, Wei Zhang, Yue Ding, Guo-ping Cai, Hui-min Zhou, Cheng-yun Liu, Jian-xiang Zhang, Zhong-min Zhao, Bu-jun Zhuang, Xiao Cheng, Zhen-lin Zhang
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer   Pages (391-403)
Wen-hao Zhao, Hua Huang, Chen Ding, Ze-xia Zhao, Chao-yi Jia, Ying-jie Wang, Zi-xuan Hu, Guan-nan Wang, Yong-wen Li, Jing-hao Liu, Hong-yu Liu, Jun Chen
Antiemetic drug fosaprepitant exerts anti-tumor effects against NSCLC by targeting FAK to inhibit AKT and JNK/c-Jun pathways   Pages (404-418)
Ying Wang, Yu-na Shao, Chen-kang Ma, Chen-ying Shu, Yi-hua Zhang, Di Lu, Hui-ling Zhang, Jian-jie Zhu, Yuan-yuan Zeng, Jian-jun Li, Zhao-wei Yan, Ze-yi Liu
Long non-coding RNA STMN1P2 promotes breast cancer doxorubicin resistance by inhibiting pyroptosis through the hnRNPU-EZH2-TARF6-MALT1-caspase-1 pathway   Pages (419-433)
You-ping Jin, Bu-jie Xu, Xiu-fen Zhang, Xue Wang, Li Wang, Lu-ying Li, Shu-yi Chen, Ping Zhu, Xiu-ling Zhi, Lei Lv, Chao-fu Wang, Zheng-lin Wang, Yang-bai Sun, Ping Zhou
NOX1 inhibition sensitizes HCC cells to sorafenib and radiotherapy by modulating ROS-mediated programmed cell death   Pages (434-443)
Wei Mu, Ya-ge Shi, Yu-lun Jian, Lei Li, Yan-feng Zhou, Hui Wang, Yang Ge
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer   Pages (444-455)
Wen-zhe Yi, Xin-di Qian, Xiao-xuan Xu, Rong Pu, Dan Yan, Zhi-wen Zhao, Ya-ping Li, Dang-ge Wang
Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects   Pages (456-466)
Peng-fei Qiang, Yao Wang, Dong-yang Zhang, Yuan-ling Yan, Hui-ting Huang, Hui-xi Yi, Hua-zhong Xie, Man Zhao, Min Li, Yuan-yuan Fu
Novel anti-HER2 nanobody-drug conjugates with enhanced penetration of solid tumor and BBB, reduced systemic exposure and superior antitumor efficacy   Pages (467-480)
Yue Wang, Liang Liu, Qi-yu Yang, Ker Yu
HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade   Pages (481-492)
Wen-jing Li, Kai-ge Kang, Yu-xiang Zhang, Xin-xin Zhao, Xi Zhu, Jiao Tang, Yong-peng Li, Hao-yu Fu, Qing Yao, Lei Wang, Li-guang Lou
TNFSF15 alleviates myeloid-derived suppressor cell-mediated cancer immunosuppression in mice   Pages (493-503)
Yi-pan Zhu, Jing Sun, Xin-yu Cao, Xin-yu Ding, Yu-ying Wang, Qiu-ju Han, Jing-ying Wang, Lu-yuan Li, Zhi-song Zhang
Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia   Pages (504-517)
Shu-qing Chu, Yi-jie Chen, Rui-rui Yang, Dan Teng, Gui-zhen Zhou, Ying-ying Zhang, Bu-ying Niu, Jia-hang Xu, Ke-xin Lin, Xin-yu Yang, Xu-tong Li, Ming-yue Zheng, Su-lin Zhang
Harnessing deep statistical potential for biophysical scoring of protein-peptide interactions   Pages (518-532)
De-jun Jiang, Hui-feng Zhao, Hong-yan Du, Yu Kang, Pei-chen Pan, Zhen-xing Wu, Yun-dian Zeng, O-din Zhang, Xiao-rui Wang, Ji-ke Wang, Yuan-sheng Huang, Yi-hao Zhao, Chang-Yu Hsieh, Dong-sheng Cao, Hui-yong Sun, Ting-jun Hou
Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans   Pages (533-544)
Zi-tao Guo, Hong Wang, Ning-jie Xie, Yu-fan Zhou, Meng-lin Zhang, Xin-yao Kang, Jue Wang, Qing Zhu, Xiao-yan Chen

Correction

Correction: magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling   Pages (545-548)
Yan-zi Yang, Xiao-juan Zhao, Hong-jiang Xu, Shan-chun Wang, Ying Pan, Shui-juan Wang, Qiang Xu, Rui-qing Jiao, Hong-mei Gu, Ling-dong Kong