Vol 46, No 10 (October 2025): Acta Pharmacologica Sinica

Review Article

Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy   Pages (2587-2596)
Ya-nan Liang, Luo Chen, Qing-yu Huang, Yu-ting Song, Yu-juan Fan, Tong-qing Chen, Jia-hui Ni, Dong Wang, Xiao-yan Shen, Yi-ming Wang, Yan You
PRL-3: unveiling a new horizon in cancer therapy   Pages (2597-2607)
Zi-tong Cao, Jia-luo Mao, Chang-ying Huang, Han-lin Wang, Ming-zhi Wang, Wen-long Wang, Yu-bo Zhou, Jia Li

Article

OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer’s disease by deubiquitinating C/EBPβ   Pages (2608-2621)
Ling-yu She, Lu-yao Li, Hao Tang, Qin Yu, Feng-yi Gao, Yu-qing Zeng, Lin-jie Chen, Li Xiong, Li-wei Li, Fan Chen, Jin-feng Sun, Wen-hua Zheng, Xia Zhao, Guang Liang
Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice   Pages (2622-2636)
Jia-qi Zhang, Shu-yi Li, Cui Yin, Ying Ji, Xiang Zhang, Dan-yang Liu, Hang Yang, Yong Niu, Gui-yun Cui, Chun-yi Zhou, Cheng Xiao
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens   Pages (2637-2648)
Xiu-ping Fu, Ren-kun Wu, Aparna P. Shah, Bruce Ladenheim, Jesse Alt, Jean Lud Cadet, Rana Rais, Ramesh Ch, ra, Xiao-bo Cen, Jay M. Baraban
OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation   Pages (2649-2662)
Yue Luo, Wei-xin Li, Qing-song Zheng, Jue-qian Yan, Yu-die Yang, Si-rui Shen, Qian-hui Zhang, Guang Liang, Yi Wang, Ding-dao Chen, Xiang Hu, Wu Luo
Revisiting the role of GDF15 in atherosclerosis in mouse and human   Pages (2663-2676)
Mo-nan Liu, Zheng-hong Liu, Rui-xue Leng, Hans Strijdom, Jian-ping Weng, Suo-wen Xu
Ursolic acid derivative UA312 ameliorates ionizing radiation-induced cardiotoxicity and neurodevelopmental toxicity in zebrafish via targeting chrna3 and grik5   Pages (2677-2692)
Fei-fei Xu, Yue Shang, Hui-qiang Wei, Wei-ying Zhang, Li-xing Wang, Tong Hu, Shu-qin Zhang, Yan-li Li, Hai-hua Shang, Wen-bin Hou, Wen-feng Gou, Sai-jun Fan, Yi-liang Li
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis   Pages (2693-2706)
Xue-zhi Yang, Wan-kang Zhang, Zi-qing Zhu, Wei Zhao, Ling-li Luo, Lu-ping Wang, Ying-jie Zhao, Yan Chang, Wei Wei
GPR40 activation alleviates pulmonary fibrosis by repressing M2 macrophage polarization through the PKD1/CD36/TGF-β1 pathway   Pages (2707-2722)
Hui-qi Wan, Ling-feng Xie, Hong-lin Li, Yan Ma, Qiu-hui Li, Meng-qing Dai, Yuan-dong Fu, Wen-jun Li, Jin-pei Zhou, Min-yi Qian, Xu Shen
TSG attenuated NAFLD and facilitated weight loss in HFD-fed mice via activating the RUNX1/FGF21 signaling axis   Pages (2723-2733)
Zhen-lin Huang, Shao-bo Zhang, Shang-fu Xu, Xin-nan Gu, Ze-qi Wu, Yue Zhang, Jian Li, Li-li Ji
Dehydrotrametenolic acid methyl ester, a triterpenoid of Poria cocos, alleviates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation via targeting Caspase-1 in mice   Pages (2734-2750)
Ling-yan Xia, Nai-rong Yu, Su-ling Huang, Hui Qu, Li Qin, Qin-shi Zhao, Ying Leng
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer   Pages (2751-2764)
Yue Song, Yu-xiao Jiang, Jie-ying Guan, Jun-bo Jiang, Man-si Xu, Xue-ying Zhong, Li-na He, Zhen-yang Ren, Yuan Liao, Fang Liu, Yan-jun Jiang, Shan Hu, Wei Guo, Ting-xiu Zhao, Xiao-yi Liu, Jiang-yong Gu, Ya-fei Shi, Huan-huan Luo, Kun Wang, Jian-yong Xiao
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer   Pages (2765-2778)
Qiao-li Shi, Chen-ran Feng, Hui-ying Li, Pei-li Wang, Peng Chen, Xu Wei, Wen-hua Kuang, Guan-jun Li, Shi-jie Qin, Rui Liu, Rui-xing Chen, Jun-zhe Zhang, Ping Song, Yuan Yuan, Ji-gang Wang, Ling Huang
Yuanhuacine suppresses head and neck cancer growth by promoting ASCT2 degradation and inhibiting glutamine uptake   Pages (2779-2792)
Xin-yi Chen, Xin Chen, Xiao-hui Liang, Dong Lu, Rong-rong Pan, Qing-yi Xiong, Xiao-xia Liu, Jia-yi Lin, Li-jun Zhang, Hong-zhuan Chen, Jin-mei Jin, Wei-dong Zhang, Xin Luan
STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation   Pages (2793-2807)
Lei Zhang, Ling-jun Zhu, Yuan Zhao, Xin-yuan Lei, Dan-hui Wu, Kai-yue He, Meng-jie Liu, Jing-yu Yang, Jin-rong Guo, Zhi-hao Jiang, Zhen-hua Yan, Zhi-xiang Xu, Yong-ping Jian
JMC14: a novel dual PI3Kδ/CSF1R inhibitor with potent antitumor activity in hematological and solid tumors   Pages (2808-2819)
Xi Zhang, Pu Sun, Yi Wang, Lan Xu, Hui-yu Li, Lin-jiang Tong, Cun Tan, Jian Ding, Chun-hao Yang, Ling-hua Meng
Norcantharidin promotes M1 macrophage polarization and suppresses colorectal cancer growth   Pages (2820-2834) Open
Xiao-man Wei, Si-cheng Lu, Liu Li, Ying-jie Gao, Jun-yi Wang, Song-yang Xi, Ling-yu Linda Ye, Wei-xing Shen, Mian-hua Wu, Dayue Darrel Duan, Hai-bo Cheng
CD200R blockade enhances anti-tumor immunity by unleashing NK and CD8+ T cells in tumor   Pages (2835-2848)
Zheng-feng Zhang, Yu Zhang, Ya-wen Chen, Guo-shuai Cao, Xiao-dong Zheng, Rui Sun, Hui Peng, Zhi-gang Tian, Hao-yu Sun
Generating potent and persistent antitumor immunity via affinity-tuned CAR-T cells targeting mesothelin   Pages (2849-2862)
Ya-li Yue, Jun-jun Liu, Hang Ma, Zhi-di Pan, Lei Wang, Jia-wei Zhang, Shu-sheng Wang, Yue-qing Xie, Hua Jiang, Yan-lin Bian, Ming-yuan Wu, Yun-sheng Yuan, Bao-hong Zhang, Xiao-dong Xiao, Jian-wei Zhu

Correction

Correction: Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma   Pages (2863-2864)
Chan-juan Zhang, Neng Zhu, Jia Long, Hong-tao Wu, Yu-xiang Wang, Bi-yuan Liu, Duan-fang Liao, Li Qin