Vol 46, No 9 (September 2025): Acta Pharmacologica Sinica

Review Article

Targeting neurodegenerative disease-associated protein aggregation with proximity-inducing modalities   Pages (2337-2346)
Rui-xin Ge, Miao Chen, Qing-chao Li, Min Liu, Jun Zhou, Song-bo Xie
β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases   Pages (2347-2362)
Ping-ping Gao, Ling Li, Ting-ting Chen, Nan Li, Meng-qi Li, Hui-juan Zhang, Ya-ning Chen, Shi-hao Zhang, Wei Wei, Wu-yi Sun

Article

Complexin 2 contributes to the protective effect of NAD+ on neuronal survival following neonatal hypoxia-ischemia   Pages (2363-2375)
Xiao-wen Xu, Xiu-wen Zhou, Li Zhang, Qing Wang, Xin-xin Wang, Yi-ming Jin, Li-li Li, Mei-fang Jin, Hai-ying Wu, Xin Ding, Hong Ni
Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage   Pages (2376-2392)
Yu-xiao Xue, Yi-jun Chen, Mei-zhen Qin, Fan-fan Shang, Yi-ting Lu, Yu-hao Sun, Liu-guan Bian, Ao Zhang, Yang Yu, Chun-yong Ding
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1   Pages (2393-2406)
Hong Yan, Han Li, Dao-hong Yin, Zi-zhen Zhang, Qian-yun Zhang, Zhong-yu Ren, Yu Hu, Gui-yang Zheng, Yu Liu, Wen-ya Ma, Yi-ning Liu, Xiu-xiu Wang, Ben-zhi Cai, Hong-yang Chen
Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis   Pages (2407-2422)
Hua Ye, Lin Wu, Yan-mei Liu, Jun-xia Zhang, Huan-tao Hu, Mao-long Dong, Jun Ren
Pregnane X receptor alleviates sepsis-induced liver injury through activation of yes-associated protein in mice   Pages (2423-2435)
Cheng-hua Wu, Shuang Hu, Dan Li, Xiao-wen Jiang, Hui Ou-Yang, Guo-fang Bi, Peng Wang, Feng-ting Liang, Wen-hong Zhou, Xiao Yang, Jian-hong Fang, Hui-chang Bi
Direct inhibition of the TXNIP-NLRP3-GSDMD pathway reduces pyroptosis in colonocytes and alleviates ulcerative colitis in mice by the small compound PEITC   Pages (2436-2449)
Jie Wang, Cui Zhang, Jia Qin, Ning An, Mei Bai, Rong-hui Du, Yan Shen, Xu-dong Wu, Jing-cai Cheng, Xue-feng Wu, Qiang Xu
Alginate oligosaccharide prevents renal ischemia-reperfusion injury in rats via MRC1-mediated pathway   Pages (2450-2467)
Bai-en Liang, Luo-sha Long, Xin-yan Wu, Mei-ying Huang, Ying Lai, Xi Yuan, Ming-hui Wang, Meng Li, Qi-qi Zheng, Hai-ling Zhang, Man-chun Chen, Zhen-de Liu, Xin Geng, Qian-qian Lyu, Wei-dong Wang, Qing-hua Liu, Wei-zhi Liu, Chun-ling Li
JOSD2 alleviates acute kidney injury through deubiquitinating SIRT7 and negativity regulating SIRT7-NF-κB inflammatory pathway in renal tubular epithelial cells   Pages (2468-2481)
Ying Zhao, Qing-qing Zhao, Shi-jie Fan, Di-yun Xu, Li-ming Lin, Wu Luo, Bo-zhi Ye, Chun-peng Zou, Hong Zhu, Zai-shou Zhuang, Yun-jie Zhao, Guang Liang
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus   Pages (2482-2495)
Xiao Gao, Xiao-xue He, Xue-rui Zhu, Yan Wu, Jia Lu, Xin-lan Chen, Chen-shu Zhao, Hao-yu Li, Zhong-fa Zhang, Shu-wen Liu, Geng-fu Xiao, Xiao-yan Pan
Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma   Pages (2496-2508) Open
Jun-ying Wang, Meng-ping Chen, Jin-xing Jiang, Yi-ke Wan, Xin Li, Yi-wei Zhang, Yi Fang, Hong-hui Huang, Zhao-yu Qin, Jian Hou
Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis   Pages (2509-2521)
Hua Huang, Chen Ding, Wen-hao Zhao, Hong-bing Zhang, Ze-xia Zhao, Xuan-guang Li, Ying-jie Wang, Pei-jie Chen, Bo-shi Li, Xue-bing Li, Yong-wen Li, Hong-yu Liu, Jun Chen
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment   Pages (2522-2533)
Ning-ning Li, Ling-ling Rao, Dan Su, Bin-hao Liu, Guo-qiang Ma, Hong-feng Wang, Zeng-li Zhang, Zheng Ying
Ginsenoside Rh2 in combination with IFNγ potentiated the anti-cancer effect by enhancing interferon signaling response in colorectal cancer cells   Pages (2534-2546)
Mu-yang Huang, Chun-cao Xu, Qian Chen, Yan-ming Zhang, Wen-yu Lyu, Zi-han Ye, Ting Li, Ming-qing Huang, Jin-jian Lu
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates   Pages (2547-2563) Open
Jing-hong Chen, Ke-xin Li, Chao-fan Fan, Hong Yang, Zhi-rou Zhang, Yi-han Chen, Chang Qi, Ang-hua Li, An-qi Lin, Xin Chen, Peng Luo
Structural basis of the multiple ligand binding mechanisms of the P2X1 receptor   Pages (2564-2573)
Yu-ting Qiang, Peng-peng Wu, Xin Liu, Li Peng, Li-ke Zhao, Ya-ting Chen, Zhao-bing Gao, Qiang Zhao, Kun Chen

Brief Communication

Identification of indoles as potential endogenous ligands of ERRγ and their modulation on drug binding   Pages (2574-2582)
Yuan-yuan Shuai, Hong-yang Zhang, Rui Chen, Bai-ling Wang, Ping Ding, Yan Dong, Ming-ze Sun, Xi-shan Wu, Yong Xu, Yan Zhang, Jin-song Liu, Na Wang, Ting-ting Xu

Correspondence

A simple and efficient method for purification of human pluripotent stem cell-derived cardiomyocytes via activating p53   Pages (2583-2585)
Peng Zhang, Sen-le Rao, Xiao-chen Wang, Ping Liang, Ji-zhen Lu, Wen-wen Jia, Huang-tian Yang

Correction

Correction: Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway   Pages (2586)
Xia-yun Ni, Xiao-jun Feng, Zhi-hua Wang, Yang Zhang, Peter J. Little, Yang Cao, Suo-wen Xu, Li-qin Tang, Jian-ping Weng