Vol 46, No 8 (August 2025): Acta Pharmacologica Sinica

Review Article

Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets   Pages (2075-2092)
Xiao-die Gao, Jian-e Ding, Jun-xia Xie, Hua-min Xu
Targeting cholesterol metabolism: a promising therapy strategy for cancer   Pages (2093-2104)
Chun-lan Dai, Zi-yang Qiu, An-qi Wang, Shen Yan, Li-jun Zhang, Xin Luan

Article

Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice   Pages (2105-2119)
Ting-ting Li, Xiao-fan Guo, Yi-jing Zhao, Ya-hong Cheng, Dan-qing Xin, Yan Song, De-xiang Liu, Zhen Wang
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism   Pages (2120-2135)
Li-da Du, Cheng Fang, Yue-qing Wang, Zi-ying Feng, Ogunleye Femi Abiola, Zhao-lin Gao, Ju-yang Huang, Yin-zhong Ma
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation   Pages (2136-2150)
Meng-lu Song, Yun-yun Sun, Hai-jun Yin, Yi Li, Hua Yang
Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission   Pages (2151-2162)
Yu Wang, Ke-yu Hu, Qing-yang Zhang, Ying-jie Song, Ling-jie Li, Fei Wang, Gang Tian, Fan Fei, Ceng-lin Xu, Jia-jia Fang, Xu-hong Jiang, Jian-nong Wu, Wen-lu Li, Yi Wang, Zhong Chen
Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/ p-Tau pathway   Pages (2163-2179)
Jia-wen Xu, Lin Ma, Yu Xiang, Meng-qing Dai, Qiu-hui Li, Xiao-yan Jin, Yuan Ruan, Yang Li, Jia-ying Wang, Xu Shen
CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling   Pages (2180-2195) Open
Yi-hong Wen, Heng-li Zhao, Shao-yu Wu, Jia-xue Jiang, Yuan Gao, Zi-fan Wang, Xiao-yao Liu, Fei Yu, Tao Ou, An-zhi Zhao, Li-wen Chen, Jin-hua Fang, Hua-yan Wu, Jie-ning Zhu, Ning Ma, Jiu-feng Sun, Xian-hong Fang, Zhi-xin Shan
Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation   Pages (2196-2212)
Bo-xue Ren, Zhao-lan Zeng, Li Deng, Jia-meng Hu, Ming-zhen Chen, Hao-wei Jiang, Chen-zi Zang, Shen-tong Fang, Stephen J. Weiss, Jie Liu, Rong Fu, Zhao-qiu Wu
Endothelial histone deacetylase 9 promotes diabetic retinopathy in mice by regulating endothelial–mesenchymal transition   Pages (2213-2224)
Yun Bei, Ze-xu Shen, Hao-ran Lin, Tao-feng Wei, Yi-hao Wang, Zhi-tao Su, Yun-jian Dai, Yan-hong Wang, Ling-ling Huang, Tao Zhu, Wei Hu, Juan Ye, Gong-xiong Wu, Hai-bin Dai
HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis   Pages (2225-2236)
Han Wang, Yu-chen Zhao, Li Xu, Tian-jing Zhang, Liang-hu Liu, Meng-qi Zhou, Han Zhang, Yin-ning Yang, Pin Pan, Lin Jin, Zi-wei Zhang, Xian-zheng Zhang, Ling-ling Zhang
Hepatocyte cellular repressor of E1A-stimulated genes 1 protects against acetaminophen-induced liver injury by promoting autophagy   Pages (2237-2250)
Qian-ying Cheng, Miao-miao Wu, Xiao-li Wei, Li-li Lu, Run-dong Liu, Yuan-hao Li, Ni-na Zhu, Ya-qun Li, Li Zuo, Hua Wang
PU.1/Spi1 exacerbates ischemia-reperfusion induced acute kidney injury via upregulating Gata2 and promoting fibroblast activation   Pages (2251-2266)
Chen Zong, Guo-li Xu, Ming Ning, Jing-yao Li, Xin Wang, Heng-jiang Guo, Li-hong Zhang, Li Zhou, Chen Xu, Zhen-hao Yang, Li-min Lu, Jian-ying Niu
Anti-EGFR therapy can overcome acquired resistance to the third-generation ALK-tyrosine kinase inhibitor lorlatinib mediated by activation of EGFR   Pages (2267-2281)
Chen Hu, Cong-hua Lu, Jie Zheng, Jun Kang, Dai-juan Huang, Chao He, Yi-hui Liu, Zhan-rui Liu, Di Wu, Yuan-yao Dou, Yi-min Zhang, Cai-yu Lin, Rui Han, Yong He
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis   Pages (2282-2295) Open
Zhuo Wang, Yang Yang, Fang-ting Yao, Feng Zhang, Ke-ying Lin, Hong-tao Diao, Qiao-yue Zhao, Xue Kong, Wei Si, Ya-ting Xie, Jing-lun Song, Ling-hua Zeng, Chun-lei Wang, Yu-ting Xiong, Kun-kun Zou, Xiao-man Wang, Xin-yue Zhang, Han Wu, Wei-tao Jiang, Yu Bian, Bao-feng Yang
Targeting the HuR/E2F7 axis synergizes with bortezomib against multiple myeloma   Pages (2296-2309) Open
Ming-yuan Jia, Chao Wu, Ze Fu, Wen-bin Xu, Jia Liu, Cheng-yu Wu, Xin-yi Zeng, Ying-li Wu, Hua Yan
Microemulsion-based drug delivery system identifies pepper alkaloids as anti-obesity compounds   Pages (2310-2322)
Tian-kai Meng, Ruo-lei Han, Peng Ma, Shu-xin Chen, Bo-han Qi, Zi-xuan Wang, Xiao-yu Li, Han-song Deng
Transport mechanism and drug discovery of human monocarboxylate transporter 1   Pages (2323-2333)
Sai Shi, Jia-chen Li, Xiao-yu Zhou, Zhen-lu Li, Ya-xin Wang, Bing-hong Xu, Sheng Ye

Correction

Author Correction: The novel sophoridine derivate IMB-HDC induced lessened phosphorylation of STAT5a at 694 and 780 and promoted DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation   Pages (2334-2335)
Wu-li Zhao, Yan Xing, Cheng Ye, Yu-han Qiu, Yi Li, Xiu-jun Liu, Meng-yan Wang, Chong-wen Bi, Dan-qing Song, Rong-guang Shao
Correction: Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non- small cell lung cancer in mice   Pages (2336-2336)
Shi-rong Zhang, Lu-cheng Zhu, Yan-ping Jiang, Jing Zhang, Ru-jun Xu, Ya-si Xu, Bing Xia, Sheng-lin Ma