Vol 46, No 6 (June 2025): Acta Pharmacologica Sinica

Review Article

Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery   Pages (1495-1510)
Si-yuan Shen, Chao Wu, Zhi-qian Yang, Ke-xin Wang, Zhen-hua Shao, Wei Yan
Exploring immunotherapeutic strategies for neurodegenerative diseases: a focus on Huntington’s disease and Prion diseases   Pages (1511-1538)
Abhiyanta Mukherjee, Soumojit Biswas, Ipsita Roy
Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies   Pages (1539-1555)
Bo-rui Zhao, Xin-rong Hu, Wei-dong Wang, Yi Zhou

Article

Krüppel-like factor 9 alleviates Alzheimer’s disease via IDE-mediated Aβ degradation   Pages (1556-1566)
Yue-yao Feng, Jing-ran Hao, Yu-jie Zhang, Tong-tong Qiu, Meng-lin Zhang, Wei Qiao, Jin-jin Wu, Ping Qiu, Chao-fan Xu, Yin-liang Zhang, Chun-yuan Du, Zhe Pan, Yong-sheng Chang
CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus   Pages (1567-1579)
Xiao-jie Li, Shuo Wu, Zi-han Liu, An-an Liu, Hui-sheng Peng, Yu-jun Wang, Ye-xiang Chen, Jing-gen Liu, Chi Xu
GABA transporter 1 is a promising drug target for CUL4B mutation-associated epilepsy   Pages (1580-1591)
Wei Jiang, Yan-yan Ma, Yu-feng Wang, Shi-qi Jin, Rui-qi Yu, Shu-xian Chu, Yang-fan Gao, Mo-lin Wang, Yong-xin Zou, Qiao Liu, Yu Song, Yan Zheng, Chen Zhang, Gong-ping Sun, Bai-chun Jiang, Yao-qin Gong
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein   Pages (1592-1609)
Lin Guo, Na Lv, Jian-lun Ji, Ce Gao, Si-yu Liu, Zi-yu Liu, Xin-ting Lin, Zhi-dong Liu, Yun Wang
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling   Pages (1610-1623) Open
Xiao-yu Shi, Yi-xi He, Man-yue Ge, Peng Liu, Ping Zheng, Zheng-hao Li
Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathway   Pages (1624-1638)
Peng Wang, Ji-qin Yang, Dan-dan Xu, Si-jia Zhang, Shan Lu, Yong Ji
METTL14-mediated m6A methylation of pri-miR-5099 to facilitate cardiomyocyte pyroptosis in myocardial infarction   Pages (1639-1651)
Hang Yu, Qing-sui Li, Jun-nan Guo, Zhen Zhang, Xian-zhi Lang, Yi-ning Liu, Long Qin, Xu Su, Qing-wei Zhang, Ya-dong Xue, Li-ling Gong, Ning Xu, Ming Li, Wen-shuang Zhao, Xing-miao Zhao, Wan-yu Zhang, Yi-jing Yao, Xi-ming Chen, Zhen Zhang, Wei Li, Han-xiang Wang, Ben-zhi Cai, Jia-min Li, Ning Wang
SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis   Pages (1652-1663)
Zhe Chen, Jun Cheng, Qun Zhou, Le-le Wu, Jia-wei Chen, Xiang-ning Duan, Jia-long Yan, Jian-gang Cao, Xiao-dan Xia, Lan-fang Li, Lin-xi Chen
Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice   Pages (1664-1675)
Jun-kai Zhang, Xiao-ping Li, Yang Tang, Li-ping Zeng, Xuan Liu, Jian-li Zhang, Cai-yu Chen, Shuo Zheng, Zhi-zhao Liu, Xue Gong, Pedro A. Jose, Li Guo, Chun-yu Zeng
Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism   Pages (1676-1691) Open
Wei-ting Cheng, Si-ya Pei, Jie Wu, Yan-jie Wang, Yong-wen Yang, Mei-fang Xiao, Jun Chen, Yuan-yuan Wang, Li Wu, Ze-bing Huang
Neddylation of RhoA impairs its protein degradation and promotes renal interstitial fibrosis progression in diabetic nephropathy   Pages (1692-1705) Open
Xue-qi Li, Bo Jin, Si-xiu Liu, Yan Zhu, Nan Li, Qing-yan Zhang, Cheng Wan, Yuan Feng, Yue-xian Xing, Kun-ling Ma, Jing Liu, Chun-ming Jiang, Jian Lu
Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia   Pages (1706-1721)
Jian-kang Hu, Xin Tang, Guo-long Luo, Cheng Zhang, Tian-bang Wu, Chao Wang, Hui Shen, Xiao-fan Zhao, Xi-shan Wu, Jeff B. Smaill, Yong Xu, Yan Zhang, Qiu-ping Xiang
Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73   Pages (1722-1732)
Yi-xuan Wang, Li-wei Wang, Ying Huang, Lin Zhou, Guo-yu Li, Jia-wen Yang, Xue-feng Wu, Jing-cai Cheng, Qiang Xu, Yan Shen
Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit   Pages (1733-1741)
Jun-hao Deng, Hong-yue Li, Zi-yang Liu, Jing-pei Liang, Ying Ren, Yuan-ying Zeng, Ya-li Wang, Xin-liang Mao
Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma   Pages (1742-1756) Open
Bo-rui Li, Ting Wang, Hai-feng Hu, Di Wu, Chen-jie Zhou, Shun-rong Ji, Qi-feng Zhuo, Zheng Li, Zhi-liang Wang, Gui-xiong Fan, De-sheng Jing, Chong-yuan Yu, Yi Qin, Xue-min Chen, Jun-feng Xu, Xiao-wu Xu
Co-inhibition of RAGE and TLR4 sensitizes pancreatic cancer to irreversible electroporation in mice by disrupting autophagy   Pages (1757-1771)
Cui-fang Ye, Jia-di Wu, Lin-rong Li, Shu-guo Sun, Yu-gang Wang, Tian-an Jiang, Xin Long, Jun Zhao
Development of orthotopic mouse models for mid-low rectal cancer   Pages (1772-1781)
Wen Chen, Kun Shi, Dong Mo, Meng Pan, Zhong-wu Bei, Han-zhi Deng, Pei-pei Yang, Qi Tong, Li-ping Yuan, Yi-yao Wan, Jia-feng Liu, Li-li Pan, Zhi-yong Qian
Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A   Pages (1782-1793)
Hui-jun Nie, Ying-jie Fu, Shang Long, Jia-yu Wang, Wen-si Zhao, Lin-hui Zhai, Yin-long Yang, Min-jia Tan, Hao Hu, Xiao-hua Chen

Author Correction

Author Correction: Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells   Pages (1794)
Yu-chen Xiang, Peng Peng, Xue-wen Liu, Xin Jin, Jie Shen, Te Zhang, Liang Zhang, Fang Wan, Yu-liang Ren, Qing-qing Yu, Hu-zi Zhao, Yuan Si, Ying Liu

Correction

Author Correction: THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation   Pages (1795-1796)
Heng-hui Xu, Sheng-xin Hao, He-yang Sun, Xin-xin Dong, Yuan Lin, Han Lou, Li-min Zhao, Ping-ping Tang, Zi-jia Dou, Jing-jing Han, Meng-han Du, Zhou-xiu Chen, Philipp Kopylov, Dmitry Shchekochikhin, Xin Liu, Yong Zhang
Author Correction: Bicyclol protects HepG2 cells against D-galactosamine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway   Pages (1797-1798)
Xiu-qi Bao, Geng-tao Liu
Author Correction: Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling   Pages (1799)
Zhi-chao Xi, Han-gui Ren, Lin Ai, Yuan Wang, Meng-fan Liu, Yu-fei Qiu, Ji-ling Feng, Wang Fu, Qian-qian Bi, Feng Wang, Hong-xi Xu
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia   Pages (1800)
Wei Tang, Rong Cheng, Meng-yue Gao, Min-jin Hu, Lu Zhang, Qiang Wang, Xin-yu Li, Wei Yan, Xiao-ying Wang, Hai-mei Yang, Jian Cheng, Zi-chun Hua