Vol 45, No 1 (January 2024) - Acta Pharmacologica Sinica

Review Article

Neuronal K⁺-Cl^- cotransporter KCC2 as a promising drug target for epilepsy treatment Pages (1–22) Open

Erin McMoneagle, Jin Zhou, Shiyao Zhang, Weixue Huang, Sunday Solomon Josiah, Ke Ding, Yun Wang, Jinwei Zhang

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery Pages (23–35)

Si Gao, Xue-ping Liu, Ting-ting Li, Li Chen, Yi-ping Feng, Yu-kun Wang, Yan-jun Yin, Peter J. Little, Xiao-qian Wu, Suo-wen Xu, Xu-dong Jiang

Article

Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems Pages (36–51)

Ze-xian Yang, Yu Zhang, Qing Wang, Lei Zhang, Yi-fei Liu, Ye Zhang, Yu Ren, Chen Zhou, Hui-wen Gao, Nai-xia Zhang, Lin-yin Feng

Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice Pages (52–65)

Xi-zhen Ma, Lei-lei Chen, Le Qu, Hui Li, Jun Wang, Ning Song, Jun-xia Xie

Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model Pages (66–75)

An Cheng, Wenbin Jia, David I. Finkelstein, Nadia Stefanova, Haoyang Wang, Takuya Sasaki, Ichiro Kawahata, Kohji Fukunaga

Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats Pages (76–86)

Chang-peng Cui, Xue Xiong, Jia-xin Zhao, Dong-hong Fu, Yan Zhang, Peng-bo Ma, Di Wu, Bai-yan Li

SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental Parkinson’s disease Pages (87–97)

Wei Yu, Lin Wang, Wei-ying Ren, Hai-xia Xu, Ne N. Wu, Dong-hui Yu, Russel J. Reiter, Wen-liang Zha, Qing-dong Guo, Jun Ren

Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling Pages (98–111)

Shuang Yang, Hou-wei Li, Jia-ying Tian, Zheng-kai Wang, Yi Chen, Ting-ting Zhan, Chun-yue Ma, Min Feng, Shi-feng Cao, Yu Zhao, Xue Li, Jing Ren, Qian Liu, Lu-ying Jin, Zhi-qi Wang, Wen-yu Jiang, Yi-xiu Zhao, Yan Zhang, Xue Liu

Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation Pages (112–124)

Yi-min Huang, Yu-sen Wu, Yuan-ye Dang, Yi-ming Xu, Kong-yang Ma, Xiao-yan Dai

PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release Pages (125–136)

Jing-yao Li, Xi-ang Sun, Xin Wang, Ning-hao Yang, Hong-yan Xie, Heng-jiang Guo, Li Lu, Xin Xie, Li Zhou, Jun Liu, Wei Zhang, Li-min Lu

Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway Pages (137–149)

Hua Miao, Yan-ni Wang, Wei Su, Liang Zou, Shou-gang Zhuang, Xiao-yong Yu, Fei Liu, Ying-yong Zhao

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis Pages (150–165)

Bo Wang, Li-na Yang, Le-tian Yang, Yan Liang, Fan Guo, Ping Fu, Liang Ma

DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K- Akt-NF-κB pathway Pages (166–179)

Chun-mei Wu, Jia-wen Mao, Jin-zhi Zhu, Can-can Xie, Jia-ying Yao, Xiao-qian Yang, Mai Xiang, Yi-fan He, Xiao Tong, Dilinaer Litifu, Xiao-yu Xiong, Meng-nan Cheng, Feng-hua Zhu, Shi-jun He, Ze-min Lin, Jian-ping Zuo

Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199 Pages (180–192)

Wen-xiang Ren, Hao Guo, Sheng-yan Lin, Si-yi Chen, Yao-ying Long, Liu-yue Xu, Di Wu, Yu-lin Cao, Jiao Qu, Bian-lei Yang, Hong-pei Xu, He Li, Ya-li Yu, An-yuan Zhang, Shan Wang, Yi-cheng Zhang, Ke-shu Zhou, Zhi-chao Chen, Qiu-bai Li

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis Pages (193–208)

Huan Liu, Rui Deng, Cheng-wei Zhu, Hong-kuan Han, Gang-fan Zong, Lang Ren, Peng Cheng, Zhong-hong Wei, Yang Zhao, Su-yun Yu, Yin Lu

S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome Pages (209–222)

Yi-hui Yang, Wan Li, Li-wen Ren, Hong Yang, Yi-zhi Zhang, Sen Zhang, Yue Hao, Dong-ke Yu, Rong-sheng Tong, Guan-hua Du, Jian-you Shi, Jin-hua Wang

Vol 45, No 1 (January 2024): Acta Pharmacologica Sinica

Review Article

Neuronal K⁺-Cl^- cotransporter KCC2 as a promising drug target for epilepsy treatment Pages (1–22) Open

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery Pages (23–35)

Article

Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems Pages (36–51)

Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice Pages (52–65)

Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model Pages (66–75)

Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats Pages (76–86)

SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental Parkinson’s disease Pages (87–97)

Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling Pages (98–111)

Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation Pages (112–124)

PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release Pages (125–136)

Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway Pages (137–149)

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis Pages (150–165)

DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K- Akt-NF-κB pathway Pages (166–179)

Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199 Pages (180–192)

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis Pages (193–208)

S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome Pages (209–222)

Table of Contents

Cover Image

Vol 45, No 1 (January 2024): Acta Pharmacologica Sinica

Review Article

Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment Pages (1–22) Open

Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery Pages (23–35)

Article

Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems Pages (36–51)

Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice Pages (52–65)

Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model Pages (66–75)

Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats Pages (76–86)

SGLT2 inhibitor empagliflozin alleviates cardiac remodeling and contractile anomalies in a FUNDC1-dependent manner in experimental Parkinson’s disease Pages (87–97)

Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling Pages (98–111)

Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation Pages (112–124)

PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release Pages (125–136)

Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway Pages (137–149)

Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis Pages (150–165)

DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K- Akt-NF-κB pathway Pages (166–179)

Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199 Pages (180–192)

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis Pages (193–208)

S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome Pages (209–222)

Table of Contents

Cover Image

Neuronal K⁺-Cl^- cotransporter KCC2 as a promising drug target for epilepsy treatment Pages (1–22) Open