Vol 44, No 4 (April 2023) - Acta Pharmacologica Sinica

Review Article

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies Pages (695–709)

Suo-wen Xu, Iqra Ilyas, Jian-ping Weng

CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication Pages (710–725)

Huan Zhang, Zi-yin Zhang-Sun, Cheng-xu Xue, Xi-yang Li, Jun Ren, Yu-ting Jiang, Tong Liu, Hai-rong Yao, Juan Zhang, Tian-tian Gou, Ye Tian, Wang-rui Lei, Yang Yang

Article

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy Pages (726–740)

Lei Li, Jing-jing Song, Meng-xue Zhang, Hui-wen Zhang, Hai-yan Zhu, Wei Guo, Cai-long Pan, Xue Liu, Lu Xu, Zhi-yuan Zhang

Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice Pages (741–751)

Chen Hong, Zhi Wang, Si-li Zheng, Wen-jun Hu, Shu-na Wang, Yan Zhao, Chao-yu Miao

Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model Pages (752–765)

Yeojin Bang, Yoonjung Kwon, Mihyang Kim, Soung Hee Moon, Kiwon Jung, Hyun Jin Choi

Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Pages (766–779)

Jing-xian Sun, Ke-ying Zhu, Yu-meng Wang, Dan-jie Wang, Mi-zhen Zhang, Heela Sarlus, Irene Benito-Cuesta, Xiao-qiang Zhao, Zao-feng Zou, Qing-yang Zhong, Yi Feng, Shuai Wu, Yan-qing Wang, Robert A. Harris, Jun Wang

Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC Pages (780–790)

Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease Pages (791–800)

Jia Song, Rui-rui Yang, Jie Chang, Ya-dan Liu, Cheng-hao Lu, Li-fan Chen, Hao Guo, Ying-hui Zhang, Zi-sheng Fan, Jing-yi Zhou, Gui-zhen Zhou, Ke-ke Zhang, Xiao-min Luo, Kai-xian Chen, Hua-liang Jiang, Su-lin Zhang, Ming-yue Zheng

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1 Pages (801–810)

Zuo-wei Wang, Feng-ming Zou, Ao-li Wang, Jing Yang, Rui Jin, Bei-lei Wang, Li-juan Shen, Shuang Qi, Juan Liu, Jing Liu, Wen-chao Wang, Qing-song Liu

TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca²⁺ oscillation Pages (811–821)

Ping Jiang, Song-shan Li, Xin-feng Xu, Chan Yang, Chen Cheng, Jin-shen Wang, Ping-zheng Zhou, Shu-wen Liu

Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα Pages (822–831)

Qian-qian Wang, Liaqat Hussain, Pei-han Yu, Chang Yang, Chen-ying Zhu, Ya-fang Ma, Si-chun Wang, Tao Yang, Yuan-yuan Kang, Wen-juan Yu, Yasen Maimaitiyiming, Hua Naranmandura

Comparison of two methods for tumour-targeting peptide modification of liposomes Pages (832–840)

Shi-qi Huang, Han-ming Zhang, Yi-cong Zhang, Lu-yao Wang, Zhi-rong Zhang, Ling Zhang

Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors Pages (841–852)

Guo-zhen Cao, Li-ying Ma, Zong-hui Zhang, Xiao-lin Wang, Jing-han Hua, Jia-hui Zhang, Yang Lv, Shao-bo Zhang, Jian Ou, Wen-chu Lin

SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16 Pages (853–864)

Yuan Liu, Wei-yao Kong, Cui-fu Yu, Zhen-long Shao, Qiu-cheng Lei, Yuan-fei Deng, Geng-xi Cai, Xue-fen Zhuang, Wen-shuang Sun, Shi-gang Wu, Rong Wang, Xiang Chen, Guo-xing Chen, Hong-biao Huang, Yu-ning Liao

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway Pages (865–876) Open

Chang-feng Song, Yu-heng Hu, Zhi-guo Mang, Zeng Ye, Hai-di Chen, De-sheng Jing, Gui-xiong Fan, Shun-rong Ji, Xian-jun Yu, Xiao-wu Xu, Yi Qin

Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma Pages (877–887)

Qi-lei Han, Xiang-lei Zhang, Peng-xuan Ren, Liang-he Mei, Wei-hong Lin, Lin Wang, Yu Cao, Kai Li, Fang Bai

DrugRep: an automatic virtual screening server for drug repurposing Pages (888–896)

Jian-hong Gan, Ji-xiang Liu, Yang Liu, Shu-wen Chen, Wen-tao Dai, Zhi-Xiong Xiao, Yang Cao

JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice Pages (897–912)

Zhan Xie, Xin-jing Wu, Rui-wen Cheng, Jia-hua Cui, Song-tao Yuan, Jian-wei Zhou, Qing-huai Liu

Vol 44, No 4 (April 2023): Acta Pharmacologica Sinica

Review Article

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies Pages (695–709)

CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication Pages (710–725)

Article

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy Pages (726–740)

Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice Pages (741–751)

Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model Pages (752–765)

Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Pages (766–779)

Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC Pages (780–790)

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease Pages (791–800)

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1 Pages (801–810)

TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca²⁺ oscillation Pages (811–821)

Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα Pages (822–831)

Comparison of two methods for tumour-targeting peptide modification of liposomes Pages (832–840)

Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors Pages (841–852)

SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16 Pages (853–864)

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway Pages (865–876) Open

Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma Pages (877–887)

DrugRep: an automatic virtual screening server for drug repurposing Pages (888–896)

JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice Pages (897–912)

Table of Contents

Cover Image

Vol 44, No 4 (April 2023): Acta Pharmacologica Sinica

Review Article

Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies Pages (695–709)

CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication Pages (710–725)

Article

Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy Pages (726–740)

Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice Pages (741–751)

Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model Pages (752–765)

Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function Pages (766–779)

Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC Pages (780–790)

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease Pages (791–800)

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1 Pages (801–810)

TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation Pages (811–821)

Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα Pages (822–831)

Comparison of two methods for tumour-targeting peptide modification of liposomes Pages (832–840)

Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors Pages (841–852)

SNS-023 sensitizes hepatocellular carcinoma to sorafenib by inducing degradation of cancer drivers SIX1 and RPS16 Pages (853–864)

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway Pages (865–876) Open

Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma Pages (877–887)

DrugRep: an automatic virtual screening server for drug repurposing Pages (888–896)

JP1, a polypeptide specifically targeting integrin αVβ3, ameliorates choroidal neovascularization and diabetic retinopathy in mice Pages (897–912)

Table of Contents

Cover Image

TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca²⁺ oscillation Pages (811–821)