Vol 43, No 6 (June 2022): Acta Pharmacologica Sinica

Review Article

Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy   Pages (1337–1348)
Qing Li, Ming Xiang

Article

Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction   Pages (1349–1359)
Ruo-bing Guo, Yin-feng Dong, Zhi Yin, Zhen-yu Cai, Jin Yang, Juan Ji, Yu-qin Sun, Xin-xin Huang, Teng-fei Xue, Hong Cheng, Xi-qiao Zhou, Xiu-lan Sun
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury   Pages (1360–1371)
Yan-qing Wu, Jun Xiong, Zi-li He, Yuan Yuan, Bei-ni Wang, Jing-yu Xu, Man Wu, Su-su Zhang, Shu-fang Cai, Jia-xin Zhao, Ke Xu, Hong-yu Zhang, Jian Xiao
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion   Pages (1372–1382)
Yuan-yuan Wei, Yan Ma, Song-yu Yao, Ling-hui Kong, Xiao Liu, Jing-rui Chai, Jing Chen, Wei Li, Yu-jun Wang, Li-ming Shao, Jing-gen Liu
LncRNA-6395 promotes myocardial ischemia-reperfusion injury in mice through increasing p53 pathway   Pages (1383–1394)
Lin-feng Zhan, Qi Zhang, Lu Zhao, Xue Dong, Xin-yu Pei, Li-li Peng, Xiao-wen Zhang, Bo Meng, Wen-di Shang, Zhen-wei Pan, Chao-qian Xu, Yan-jie Lu, Ming-yu Zhang
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism   Pages (1395–1407)
Fan Qiu, Yi Yuan, Wei Luo, Yan-shan Gong, Zhong-ming Zhang, Zhong-min Liu, Ling Gao
Antiatherosclerotic effect of dehydrocorydaline on ApoE−/− mice: inhibition of macrophage inflammation   Pages (1408–1418) Open
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome   Pages (1419–1429)
Xiao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-jing Lai, Fang-jie Wang, Meng Meng, Bang-hui Mo, Pei Huang, Ting-ting You, Ya-fei Deng, Liang Song, Wei Guo, Ping Yi, Jian-hua Yu, Yuan Gao, Wei-nian Shou, Bing-bo Chen, You-cai Deng, Xiao-hui Li
Small molecule compound M12 reduces vascular permeability in obese mice via blocking endothelial TRPV4–Nox2 interaction   Pages (1430–1440)
Meng-ru Gao, Peng Zhang, Jing Han, Chun-lei Tang, Yi-fei Zhu, Hao Kan, Hong-juan Li, Xi-ping Han, Xin Ma
All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway   Pages (1441–1452)
Han-yu Yang, Ming Liu, Yun Sheng, Liang Zhu, Meng-meng Jin, Tian-xin Jiang, Lu Yang, Pei-hua Liu, Xiao-dong Liu, Li Liu
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors   Pages (1453–1460)
Yu-zhe Wang, De-hua Yang, Ming-wei Wang
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids   Pages (1461–1472)
Min Liu, Yi Liu, Lin-guo Pei, Qi Zhang, Hao Xiao, Ya-wen Chen, Hui Wang
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway   Pages (1473–1483)
Yi-kuan Wu, Zheng-nan Ren, Sheng-long Zhu, Yun-zhou Wu, Gang Wang, Hao Zhang, Wei Chen, Zhao He, Xian-long Ye, Qi-xiao Zhai
IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver   Pages (1484–1494)
Li-na Zhao, Hong-feng Yuan, Yu-fei Wang, Hao-lin Yun, Wei Zheng, Ying Yuan, Yu Geng, Man Zhao, Lian-yun Feng, Xiao-dong Zhang
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s   Pages (1495–1507)
Yan-yang Li, Xiao-jing Wang, Yu-lin Su, Qing Wang, Shao-wei Huang, Zeng-feng Pan, Yan-ping Chen, Jun-jie Liang, Mei-ling Zhang, Xue-qian Xie, Zhi-yun Wu, Jin-yan Chen, Lian Zhou, Xia Luo
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays   Pages (1508–1520)
Yu Zhang, Lei Xu, Yao Zhang, Jie Pan, Pu-qing Wang, Sheng Tian, Huan-ting Li, Bo-wen Gao, Ting-jun Hou, Xue-chu Zhen, Long-Tai Zheng
Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells   Pages (1521–1533) Open
Li-jun Du, Yu-xiang Feng, Zhi-xing He, Lin Huang, Qiao Wang, Cheng-ping Wen, Yun Zhang
GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib   Pages (1534–1543)
Le-ying Chen, Qing You, Da-zhao Lv, Shuai-hu Li, Shi-yi Zhang
Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ ITGβ5 signaling   Pages (1544–1555)
Yue-qiang Chen, Hai-yan Song, Zhong-yan Zhou, Jiao Ma, Zhan-yang Luo, Ying Zhou, Jian-yi Wang, Sheng Liu, Xiang-hui Han
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment   Pages (1556–1567)
Lei Wang, Lin Zhao, Fu-lian Gong, Chao Sun, Dan-dan Du, Xiao-xia Yang, Xiu-li Guo
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells   Pages (1568–1580)
Yu-chen Xiang, Peng Peng, Xue-wen Liu, Xin Jin, Jie Shen, Te Zhang, Liang Zhang, Fang Wan, Yu-liang Ren, Qing-qing Yu, Hu-zi Zhao, Yuan Si, Ying Liu
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming   Pages (1581–1593)
Ping Wang, Jin-mei Jin, Xiao-hui Liang, Ming-zhu Yu, Chun Yang, Fei Huang, Hui Wu, Bei-bei Zhang, Xiao-yan Fei, Zheng-tao Wang, Ren Xu, Hai-lian Shi, Xiao-jun Wu
Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction   Pages (1594–1604) Open
Hai-yan Wang, Pian Yu, Xi-sha Chen, Hui Wei, Shi-jie Cao, Meng Zhang, Yi Zhang, Yong-guang Tao, Dong-sheng Cao, Feng Qiu, Yan Cheng
Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening   Pages (1605–1615)
Xue-ping Hu, Liu Yang, Xin Chai, Yi-xuan Lei, Md Shah Alam, Lu Liu, Chao Shen, De-jun Jiang, Zhe Wang, Zhi-yong Liu, Lei Xu, Kang-lin Wan, Tian-yu Zhang, Yue-lan Yin, Dan Li, Dong-sheng Cao, Ting-jun Hou

Correction

Author Correction: Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling   Pages (1616)
Yan-zi Yang, Xiao-juan Zhao, Hong-jiang Xu, Shan-chun Wang, Ying Pan, Shui-juan Wang, Qiang Xu, Rui-qing Jiao, Hong-mei Gu, Ling-dong Kong
Author Correction: Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling   Pages (1617–1618)
Cheng-gui Wang, Yi-ting Lou, Min-ji Tong, Li-lian Zhang, Zeng-jie Zhang, Yong-zeng Feng, Shi Li, Hua-zi Xu, Cong Mao

Author Correction

Author Correction: Inactivation of TSC1 promotes epithelial–mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy   Pages (1619–1620)
Qian Lu, Yi-bing Chen, Hao Yang, Wen-wen Wang, Cheng-cheng Li, Lei Wang, Jin Wang, Lei Du, Xiao-xing Yin

Retraction Note

Retraction Note to: Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway   Pages (1621)
Mei Han, Hui Gao, Jing Xie, Yin-ping Yuan, Quan Yuan, Ming-quan Gao, Kai-li Liu, Xue-hong Chen, Yan-tao Han, Zhi-wu Han
Retraction Note: Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation   Pages (1622)
Hui Gao, Ming-quan Gao, Jian-jun Peng, Mei Han, Kai-li Liu, Yan-tao Han