Vol 42, No 11 (November 2021) - Acta Pharmacologica Sinica

Review Article

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications Pages (1725–1741)

Hai-feng Hu, Zeng Ye, Yi Qin, Xiao-wu Xu, Xian-jun Yu, Qi-feng Zhuo, Shun-rong Ji

NOD-like receptors in autoimmune diseases Pages (1742–1756)

Li Chen, Shi-qi Cao, Ze-min Lin, Shi-jun He, Jian-ping Zuo

Article

Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media Pages (1757–1768) Open

Peng Zeng, Qiu-hong Hua, Jun-yuan Gong, Chang-jie Shi, Xiao-ping Pi, Xin Xie, Ru Zhang

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis Pages (1769–1779)

Rui-yuan Pan, Xiang-xi Kong, Yong Cheng, Lu Du, Zhen-chao Wang, Chao Yuan, Jin-bo Cheng, Zeng-qiang Yuan, Hai-yan Zhang, Ya-jin Liao

Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression Pages (1780–1789)

Gen-long Xue, De-sheng Li, Zhi-yong Wang, Yang Liu, Ji-ming Yang, Chang-zhu Li, Xing-da Li, Jiu-dong Ma, Man-man Zhang, Yan-jie Lu, Yue Li, Bao-feng Yang, Zhen-wei Pan

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43 Pages (1790–1797)

Jia-dan Wang, Ying Shao, Dan Liu, Nuo-ya Liu, Dan-yan Zhu

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats Pages (1798–1807)

Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu

Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation Pages (1808–1820)

Zhen-ning Lu, Wei-xiao Niu, Na Zhang, Mao-xu Ge, Yun-yang Bao, Yu Ren, Xiu-li Guo, Hong-wei He

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation Pages (1821–1833) Open

Jin-dong Zhang, Jiao Liu, Shi-wei Zhu, Yuan Fang, Ben Wang, Qiong Jia, Hui-feng Hao, John Y. Kao, Qi-hua He, Li-jin Song, Fei Liu, Bao-li Zhu, Chung Owyang, Li-ping Duan

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice Pages (1834–1846)

Yu-ran Ren, Yang-liang Ye, Ying Feng, Ti-fei Xu, Yu Shen, Jia Liu, Su-ling Huang, Jian-hua Shen, Ying Leng

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis Pages (1847–1859)

Cheng-lin Li, Juan Li, Shu-yuan Gong, Meng Huang, Rui Li, Gui-xiang Xiong, Fan Wang, Qiu-ming Zou, Qi Qi, Xiao-xing Yin

Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy Pages (1860–1874)

Zhen-zhen Liu, Xiao-ning Liu, Rui-cheng Fan, Yu-ping Jia, Qing-ke Zhang, Xin-qing Gao, Yu-qing Wang, Meng-qing Yang, Li-zhen Ji, Yong-qing Zhou, Hong-li Li, Ping Li, Bo Tang

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin Pages (1875–1887)

Xiao-ming Huang, Jia-jun Huang, Jing-jing Du, Na Zhang, Ze Long, You Yang, Fang-fang Zhong, Bo-wen Zheng, Yun-fu Shen, Zhe Huang, Xiang Qin, Jun-he Chen, Qian-yu Lin, Wan-jun Lin, Wen-zhe Ma

The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53 Pages (1888–1899)

Wen-fang Li, Arin Herkilini, Yu Tang, Ping Huang, Guan-bin Song, Makoto Miyagishi, Vivi Kasim, Shou-rong Wu

G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin Pages (1900–1912)

Cong-hui Zhang, Hong Liu, Wu-li Zhao, Wen-xia Zhao, Hui-min Zhou, Rong-guang Shao

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases Pages (1913–1920)

An-te Ou, Jia-xin Zhang, Yue-fei Fang, Rong Wang, Xue-ping Tang, Peng-fei Zhao, Yu-ge Zhao, Meng Zhang, Yong-zhuo Huang

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1 Pages (1921–1929)

Wan-ting Zhang, Ting-ting Liu, Man Wu, Xiao-chen Chen, Li Han, Zhen-zhong Shi, Yu-ying Li, Xi-yang Li, Hai-xing Xu, Li-kun Gong, Pei-hu Xu, Yong Geng

Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization Pages (1930–1941)

Xiao-yang Chen, Fei Qian, Yao-yao Wang, Yan Liu, Yuan Sun, Wei-bin Zha, Kun Hao, Fang Zhou, Guang-ji Wang, Jing-wei Zhang

Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins Pages (1942–1950)

Tong Wu, Yun Sheng, Yuan-yuan Qin, Wei-min Kong, Meng-meng Jin, Han-yu Yang, Xiao-ke Zheng, Chang Dai, Ming Liu, Xiao-dong Liu, Li Liu

Vol 42, No 11 (November 2021): Acta Pharmacologica Sinica

Review Article

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications Pages (1725–1741)

NOD-like receptors in autoimmune diseases Pages (1742–1756)

Article

Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media Pages (1757–1768) Open

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis Pages (1769–1779)

Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression Pages (1780–1789)

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43 Pages (1790–1797)

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats Pages (1798–1807)

Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation Pages (1808–1820)

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation Pages (1821–1833) Open

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice Pages (1834–1846)

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis Pages (1847–1859)

Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy Pages (1860–1874)

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin Pages (1875–1887)

The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53 Pages (1888–1899)

G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin Pages (1900–1912)

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases Pages (1913–1920)

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1 Pages (1921–1929)

Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization Pages (1930–1941)

Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins Pages (1942–1950)

Table of Contents

Cover Image

Vol 42, No 11 (November 2021): Acta Pharmacologica Sinica

Review Article

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications Pages (1725–1741)

NOD-like receptors in autoimmune diseases Pages (1742–1756)

Article

Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media Pages (1757–1768) Open

1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis Pages (1769–1779)

Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression Pages (1780–1789)

Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43 Pages (1790–1797)

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats Pages (1798–1807)

Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation Pages (1808–1820)

Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation Pages (1821–1833) Open

SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice Pages (1834–1846)

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis Pages (1847–1859)

Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy Pages (1860–1874)

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin Pages (1875–1887)

The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53 Pages (1888–1899)

G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin Pages (1900–1912)

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases Pages (1913–1920)

Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1 Pages (1921–1929)

Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization Pages (1930–1941)

Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins Pages (1942–1950)

Table of Contents

Cover Image

Identification of pimavanserin tartrate as a potent Ca²⁺-calcineurin-NFAT pathway inhibitor for glioblastoma therapy Pages (1860–1874)