Vol 42, No 3 (March 2021) - Acta Pharmacologica Sinica

Article

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress Pages (347–360)

Bei-ni Wang, Cheng-biao Wu, Zi-miao Chen, Pei-pei Zheng, Ya-qian Liu, Jun Xiong, Jing-yu Xu, Pei-feng Li, Abdullah Al Mamun, Li-bing Ye, Zhi-long Zheng, Yan-qing Wu, Jian Xiao, Jian Wang

Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention Pages (361–369)

Meng Mao, Lin Yang, Zhuo Jin, Ling-xu Li, Yan-ru Wang, Ting-ting Li, Ya-jun Zhao, Jing Ai

Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway Pages (370–381)

Cheng-di Liu, Nan-nan Liu, Sen Zhang, Guo-dong Ma, Hai-guang Yang, Ling-lei Kong, Guan-hua Du

Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression Pages (382–392)

Zhong-fang Shi, Qing Fang, Ye Chen, Li-xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-xuan Wang, Yu-jiao Wang, Xu Yan, Li-ping Dong, Fang Yuan

Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress Pages (393–403)

Jia-hui Tian, Qian Wu, Yong-xiang He, Qi-ying Shen, Mubarak Rekep, Gui-ping Zhang, Jian-dong Luo, Qin Xue, Ying-hua Liu

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism Pages (404–413)

Ying Tan, Hong-hong Wan, Ming-ming Sun, Wen-jing Zhang, Maolong Dong, Wei Ge, Jun Ren, Hu Peng

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1 Pages (414–421)

Fang-fang Li, Yu-lai Liang, Xiao-shuai Han, Ya-na Guan, Jian Chen, Ping Wu, Xian-xian Zhao, Qing Jing

Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon Pages (422–435)

Yu-meng Miao, Ya-jing Zhang, Si-miao Qiao, Yu-feng Xia, Zhi-feng Wei, Yue Dai

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury Pages (436–450)

Dan Xu, Pan-pan Chen, Pei-qing Zheng, Fan Yin, Qian Cheng, Zhuan-li Zhou, Hong-yan Xie, Jing-yao Li, Jia-yun Ni, Yan-zhe Wang, Si-jia Chen, Li Zhou, Xiao-xia Wang, Jun Liu, Wei Zhang, Li-min Lu

TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Pages (451–459)

Xiao-ming Jiang, Yu-lian Xu, Luo-wei Yuan, Le-le Zhang, Mu-yang Huang, Zi-han Ye, Min-xia Su, Xiu-ping Chen, Hong Zhu, Richard D. Ye, Jin-jian Lu

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation Pages (460–469)

Yu-hang Zhang, Shu-xiang Cui, Sheng-biao Wan, Shu-hua Wu, Xian-jun Qu

Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine Pages (470–481)

Qiu-shi Xie, Jia-xin Zhang, Ming Liu, Pei-hua Liu, Zhong-jian Wang, Liang Zhu, Ling Jiang, Meng-meng Jin, Xiao-nan Liu, Li Liu, Xiao-dong Liu

Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor Pages (482–490)

Qian-qian Tian, Yun-ting Zhu, Xing-xing Diao, Xiang-lei Zhang, Ye-chun Xu, Xiang-rui Jiang, Jing-shan Shen, Zhen Wang, Da-fang Zhong

Review Article

Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues Pages (323–339)

Mi Li, Ning Xi, Yue-chao Wang, Lian-qing Liu

Zinc as a countermeasure for cadmium toxicity Pages (340–346)

Hai-tao Yu, Juan Zhen, Ji-yan Leng, Lu Cai, Hong-lei Ji, Bradley B. Keller

Brief Communication

Synthesis and preliminary evaluation of novel ¹¹C-labeled GluN2B-selective NMDA receptor negative allosteric modulators Pages (491–498)

Ji-yun Sun, Katsushi Kumata, Zhen Chen, Yi-ding Zhang, Jia-hui Chen, Akiko Hatori, Hua-long Fu, Jian Rong, Xiao-yun Deng, Tomoteru Yamasaki, Lin Xie, Kuan Hu, Masayuki Fujinaga, Qing-zhen Yu, Tuo Shao, Thomas Lee Collier, Lee Josephson, Yi-han Shao, Yun-fei Du, Lu Wang, Hao Xu, Ming-rong Zhang, Steven H Liang

Vol 42, No 3 (March 2021): Acta Pharmacologica Sinica

Article

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress Pages (347–360)

Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention Pages (361–369)

Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway Pages (370–381)

Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression Pages (382–392)

Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress Pages (393–403)

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism Pages (404–413)

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1 Pages (414–421)

Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon Pages (422–435)

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury Pages (436–450)

TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Pages (451–459)

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation Pages (460–469)

Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine Pages (470–481)

Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor Pages (482–490)

Review Article

Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues Pages (323–339)

Zinc as a countermeasure for cadmium toxicity Pages (340–346)

Brief Communication

Synthesis and preliminary evaluation of novel ¹¹C-labeled GluN2B-selective NMDA receptor negative allosteric modulators Pages (491–498)

Table of Contents

Cover Image

Vol 42, No 3 (March 2021): Acta Pharmacologica Sinica

Article

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress Pages (347–360)

Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention Pages (361–369)

Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway Pages (370–381)

Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression Pages (382–392)

Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress Pages (393–403)

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism Pages (404–413)

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1 Pages (414–421)

Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon Pages (422–435)

KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury Pages (436–450)

TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance Pages (451–459)

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation Pages (460–469)

Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine Pages (470–481)

Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor Pages (482–490)

Review Article

Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues Pages (323–339)

Zinc as a countermeasure for cadmium toxicity Pages (340–346)

Brief Communication

Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators Pages (491–498)

Table of Contents

Cover Image

Synthesis and preliminary evaluation of novel ¹¹C-labeled GluN2B-selective NMDA receptor negative allosteric modulators Pages (491–498)