Vol 42, No 2 (February 2021) - Acta Pharmacologica Sinica

Review Article

Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies Pages (171–178)

Xia-qing Xu, Xiao-hui Pan, Ting-ting Wang, Jian Wang, Bo Yang, Qiao-jun He, Ling Ding

Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence? Pages (179–188)

Chen-xi Zhao, Chen-ming Zeng, Ke Wang, Qiao-jun He, Bo Yang, Fan-fan Zhou, Hong Zhu

Article

D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice Pages (189–198)

Dong-liang Tang, Yi-wen Luan, Chun-yi Zhou, Cheng Xiao

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice Pages (199–208)

Man Wu, Guang Lu, Yuan-zhi Lao, Hong Zhang, Dan Zheng, Zhao-qing Zheng, Juan Yi, Qian Xiang, Li-ming Wang, Hong-sheng Tan, Hua Zhou, Han-ming Shen, Hong-xi Xu

Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts Pages (209–217)

Pei-pei Zhang, Zhao-fu Guo, Pei-hua Zhang, Zhi-pei Liu, Lv Song, Ze-fu Zhang, Yu-zhong Jia, Zhen-zhen Cao, Ji-hua Ma

Inhibition of the I_Na/K and the activation of peak I_Na contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs Pages (218–229)

Xiang-chong Wang, Qing-zhong Jia, Yu-lou Yu, Han-dong Wang, Hui-cai Guo, Xin-di Ma, Chun-tong Liu, Xue-yan Chen, Qing-feng Miao, Bing-cai Guan, Su-wen Su, He-ming Wei, Chuan Wang

Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation Pages (230–241)

Shu Song, Yue Ding, Guo-liang Dai, Yue Zhang, Meng-ting Xu, Jie-ru Shen, Ting-ting Chen, Yun Chen, Guo-liang Meng

Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy Pages (242–251)

Lei Du, Xuan Qian, Yuan Li, Xi-zhi Li, Lin-lin He, Liu Xu, Yi-qi Liu, Cheng-cheng Li, Pu Ma, Fang-lin Shu, Qian Lu, Xiao-xing Yin

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy Pages (252–263)

Tian-tian Wei, Le-tian Yang, Fan Guo, Si-bei Tao, Lu Cheng, Rong-shuang Huang, Liang Ma, Ping Fu

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis Pages (264–271)

Jun-shang Huang, Bin-bin Guo, Gai-hong Wang, Li-min Zeng, You-hong Hu, Ting Wang, He-yao Wang

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice Pages (272–281)

Yan-yan Yu, Shi-chao Cui, Tian-nan Zheng, Hai-jian Ma, Zhi-fu Xie, Hao-wen Jiang, Yu-feng Li, Ke-xin Zhu, Cheng-gang Huang, Jia Li, Jing-ya Li

Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers Pages (282–289)

Ying Li, Ya-ping Dong, You-wen Qian, Le-xing Yu, Wen Wen, Xiu-liang Cui, Hong-yang Wang

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis Pages (290–300)

Xiao-xuan Yu, Meng-yuan Zhu, Jia-rong Wang, Hui Li, Po Hu, Ying-jie Qing, Xiang-yuan Wang, Hong-zheng Wang, Zhan-yu Wang, Jing-yan Xu, Qing-long Guo, Hui Hui

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma Pages (301–310)

Zhong-jie Li, Hui-qi Dai, Xiao-wei Huang, Ji Feng, Jing-huan Deng, Zi-xuan Wang, Xiao-mei Yang, Yu-jia Liu, Yong Wu, Pan-hong Chen, Huan Shi, Ji-gang Wang, Jing Zhou, Guo-dong Lu

Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified Pages (311–322)

Lu-lu Pan, Yong Yang, Min Hui, Shuo Wang, Cui-yun Li, Hong Zhang, Yan-hua Ding, Li Fu, Xing-xing Diao, Da-fang Zhong

Vol 42, No 2 (February 2021): Acta Pharmacologica Sinica

Review Article

Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies Pages (171–178)

Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence? Pages (179–188)

Article

D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice Pages (189–198)

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice Pages (199–208)

Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts Pages (209–217)

Inhibition of the I_Na/K and the activation of peak I_Na contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs Pages (218–229)

Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation Pages (230–241)

Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy Pages (242–251)

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy Pages (252–263)

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis Pages (264–271)

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice Pages (272–281)

Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers Pages (282–289)

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis Pages (290–300)

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma Pages (301–310)

Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified Pages (311–322)

Table of Contents

Cover Image

Vol 42, No 2 (February 2021): Acta Pharmacologica Sinica

Review Article

Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies Pages (171–178)

Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence? Pages (179–188)

Article

D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice Pages (189–198)

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice Pages (199–208)

Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts Pages (209–217)

Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs Pages (218–229)

Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation Pages (230–241)

Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy Pages (242–251)

Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy Pages (252–263)

DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis Pages (264–271)

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice Pages (272–281)

Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers Pages (282–289)

LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis Pages (290–300)

Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma Pages (301–310)

Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified Pages (311–322)

Table of Contents

Cover Image

Inhibition of the I_Na/K and the activation of peak I_Na contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs Pages (218–229)