Vol 42, No 2 (February 2021): Acta Pharmacologica Sinica

Review Article

Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies   Pages (171–178)
Xia-qing Xu, Xiao-hui Pan, Ting-ting Wang, Jian Wang, Bo Yang, Qiao-jun He, Ling Ding
Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence?   Pages (179–188)
Chen-xi Zhao, Chen-ming Zeng, Ke Wang, Qiao-jun He, Bo Yang, Fan-fan Zhou, Hong Zhu


D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice   Pages (189–198)
Dong-liang Tang, Yi-wen Luan, Chun-yi Zhou, Cheng Xiao
Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice   Pages (199–208)
Man Wu, Guang Lu, Yuan-zhi Lao, Hong Zhang, Dan Zheng, Zhao-qing Zheng, Juan Yi, Qian Xiang, Li-ming Wang, Hong-sheng Tan, Hua Zhou, Han-ming Shen, Hong-xi Xu
Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts   Pages (209–217)
Pei-pei Zhang, Zhao-fu Guo, Pei-hua Zhang, Zhi-pei Liu, Lv Song, Ze-fu Zhang, Yu-zhong Jia, Zhen-zhen Cao, Ji-hua Ma
Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs   Pages (218–229)
Xiang-chong Wang, Qing-zhong Jia, Yu-lou Yu, Han-dong Wang, Hui-cai Guo, Xin-di Ma, Chun-tong Liu, Xue-yan Chen, Qing-feng Miao, Bing-cai Guan, Su-wen Su, He-ming Wei, Chuan Wang
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation   Pages (230–241)
Shu Song, Yue Ding, Guo-liang Dai, Yue Zhang, Meng-ting Xu, Jie-ru Shen, Ting-ting Chen, Yun Chen, Guo-liang Meng
Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy   Pages (242–251)
Lei Du, Xuan Qian, Yuan Li, Xi-zhi Li, Lin-lin He, Liu Xu, Yi-qi Liu, Cheng-cheng Li, Pu Ma, Fang-lin Shu, Qian Lu, Xiao-xing Yin
Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy   Pages (252–263)
Tian-tian Wei, Le-tian Yang, Fan Guo, Si-bei Tao, Lu Cheng, Rong-shuang Huang, Liang Ma, Ping Fu
DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis   Pages (264–271)
Jun-shang Huang, Bin-bin Guo, Gai-hong Wang, Li-min Zeng, You-hong Hu, Ting Wang, He-yao Wang
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice   Pages (272–281)
Yan-yan Yu, Shi-chao Cui, Tian-nan Zheng, Hai-jian Ma, Zhi-fu Xie, Hao-wen Jiang, Yu-feng Li, Ke-xin Zhu, Cheng-gang Huang, Jia Li, Jing-ya Li
Identification of important genes and drug repurposing based on clinical-centered analysis across human cancers   Pages (282–289)
Ying Li, Ya-ping Dong, You-wen Qian, Le-xing Yu, Wen Wen, Xiu-liang Cui, Hong-yang Wang
LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis   Pages (290–300)
Xiao-xuan Yu, Meng-yuan Zhu, Jia-rong Wang, Hui Li, Po Hu, Ying-jie Qing, Xiang-yuan Wang, Hong-zheng Wang, Zhan-yu Wang, Jing-yan Xu, Qing-long Guo, Hui Hui
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma   Pages (301–310)
Zhong-jie Li, Hui-qi Dai, Xiao-wei Huang, Ji Feng, Jing-huan Deng, Zi-xuan Wang, Xiao-mei Yang, Yu-jia Liu, Yong Wu, Pan-hong Chen, Huan Shi, Ji-gang Wang, Jing Zhou, Guo-dong Lu
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified   Pages (311–322)
Lu-lu Pan, Yong Yang, Min Hui, Shuo Wang, Cui-yun Li, Hong Zhang, Yan-hua Ding, Li Fu, Xing-xing Diao, Da-fang Zhong