Vol 41, No 3 (March 2020) - Acta Pharmacologica Sinica

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core Pages (293-302)

Jin-tao Wang, Yue-ming Zheng, Yue-ting Chen, Min Gu, Zhao-bing Gao, Fa-jun Nan

Propofol affects mouse embryonic ﬁbroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy Pages (303-310)

Zhen-dong Xu, Yong Wang, Ge Liang, Zhi-qiang Liu, Wu-hua Ma, Charleen T Chu, Hua-feng Wei

α₁-AR overactivation induces cardiac inﬂammation through NLRP3 inﬂammasome activation Pages (311-318)

Jun-zhou Xin, Ji-min Wu, Guo-min Hu, Hui-jun Gu, Ye-nan Feng, Shuai-xing Wang, Wen-wen Cong, Ming-zhe Li, Wen-li Xu, Yao Song, Han Xiao, You-yi Zhang, Li Wang

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis Pages (319-326)

Yu Bian, Xin Li, Ping Pang, Xue-ling Hu, Shu-ting Yu, Yi-ning Liu, Xin Li, Ning Wang, Jin-hui Wang, Wei Xiao, Wei-jie Du, Bao-feng Yang

23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9 Pages (327-335)

Hui-hui Li, Jun Li, Xian-jing Zhang, Jiao-meng Li, Cong Xi, Wen-qiong Wang, You-li Lu, Li-jiang Xuan

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice Pages (336-347)

Ying-sheng Gao, Min-yi Qian, Qiang-qiang Wei, Xu-bin Duan, Shi-lei Wang, Hai-yang Hu, Jun Liu, Chu-yue Pan, Shuo-quan Zhang, Lian-wen Qi, Jin-pei Zhou, Hui-bin Zhang, Li-rui Wang

A new recombinant MS-superoxide dismutase alleviates 5-ﬂuorouracil-induced intestinal mucositis in mice Pages (348-357)

Xiao-xia Yan, Hai-long Li, Yi-ting Zhang, Shou-yan Wu, Heng-lei Lu, Xiao-lu Yu, Fan-guo Meng, Jian-hua Sun, Li-kun Gong

A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling Pages (358-372)

Lei Du, Lei Wang, Bo Wang, Jin Wang, Meng Hao, Yi-bing Chen, Xi-zhi Li, Yuan Li, Yan-fei Jiang, Cheng-cheng Li, Hao Yang, Xiao-ke Gu, Xiao-xing Yin, Qian Lu

Asiatic acid prevents renal ﬁbrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ Pages (373-382)

Zhi-hao Zhang, Jun-qiu He, Ying-yong Zhao, Hua-chao Chen, Ning-hua Tan

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway Pages (383-393)

Xiao-lin Zhang, Ya-nan Wang, Lu-yao Ma, Zhong-sheng Liu, Fei Ye, Jian-hong Yang

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination Pages (394-403)

Ying Ren, Xin Xu, Chen-yu Mao, Kun-kun Han, Yu-jia Xu, Bi-yin Cao, Zu-bin Zhang, Gautam Sethi, Xiao-wen Tang, Xin-liang Mao

Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway Pages (404-414)

Yu-yang Ma, Ze-min Di, Qing Cao, Wen-shuang Xu, Si-xing Bi, Ji-shuang Yu, Yu-jun Shen, Yong-qiang Yu, Yu-xian Shen, Li-jie Feng

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4- (4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H- pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors Pages (415-422)

Meng-zhen Lai, Pei-ran Song, Dou Dou, Yan-yan Diao, Lin-jiang Tong, Tao Zhang, Hua Xie, Hong-lin Li, Jian Ding

Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening Pages (423-431)

Wei Guo, Sheng Yao, Pu Sun, Tian-biao Yang, Chun-ping Tang, Ming-yue Zheng, Yang Ye, Ling-hua Meng

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach Pages (432-438)

Shuo Gu, Lu-hua Lai

Vol 41, No 3 (March 2020): Acta Pharmacologica Sinica

Article

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core Pages (293-302)

Propofol affects mouse embryonic ﬁbroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy Pages (303-310)

α₁-AR overactivation induces cardiac inﬂammation through NLRP3 inﬂammasome activation Pages (311-318)

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis Pages (319-326)

23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9 Pages (327-335)

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice Pages (336-347)

A new recombinant MS-superoxide dismutase alleviates 5-ﬂuorouracil-induced intestinal mucositis in mice Pages (348-357)

A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling Pages (358-372)

Asiatic acid prevents renal ﬁbrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ Pages (373-382)

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway Pages (383-393)

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination Pages (394-403)

Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway Pages (404-414)

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4- (4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H- pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors Pages (415-422)

Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening Pages (423-431)

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach Pages (432-438)

Table of Contents

Cover Image

Vol 41, No 3 (March 2020): Acta Pharmacologica Sinica

Article

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core Pages (293-302)

Propofol affects mouse embryonic ﬁbroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy Pages (303-310)

α1-AR overactivation induces cardiac inﬂammation through NLRP3 inﬂammasome activation Pages (311-318)

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis Pages (319-326)

23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9 Pages (327-335)

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice Pages (336-347)

A new recombinant MS-superoxide dismutase alleviates 5-ﬂuorouracil-induced intestinal mucositis in mice Pages (348-357)

A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling Pages (358-372)

Asiatic acid prevents renal ﬁbrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ Pages (373-382)

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway Pages (383-393)

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination Pages (394-403)

Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway Pages (404-414)

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4- (4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H- pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors Pages (415-422)

Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening Pages (423-431)

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach Pages (432-438)

Table of Contents

Cover Image

α₁-AR overactivation induces cardiac inﬂammation through NLRP3 inﬂammasome activation Pages (311-318)