Vol 40, No 6 (June 2019) - Acta Pharmacologica Sinica

CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deﬁcits and inhibits reactive astrogliosis in rat ischemic stroke Pages (724-736)

Yuan Qin, Yang He, Yong-ming Zhu, Min Li, Yong Ni, Jin Liu, Hui-ling Zhang

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model Pages (737-745)

Li-lan Sun, Tao-yi Yang, Ning-ning Wei, Wei Lu, Wen-xuan Jiao, Qi-qi Zhou, Yong-zhen Miao, Qin Gao, Xin-tong Wang, Qi Sun, KeWei Wang

Identification and characterization of a series of novel HCN channel inhibitors Pages (746–754)

Shu-jun Chen, Yao Xu, Ye-mei Liang, Ying Cao, Jin-yan Lv, Jian-xin Pang, Ping-zheng Zhou

Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABA_A receptors Pages (755-761)

Lei Chen, Zhi-lai Yang, Juan Cheng, Ping-ping Zhang, Le-sha Zhang, Xue-sheng Liu, Lie-cheng Wang

Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients Pages (762-768)

Yi-bei Chen, Zi-yi Zhou, Guo-min Li, Can-xing Xiao, Wei-bang Yu, Shi-long Zhong, Ye-feng Cai, Jing Jin, Min Huang

Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury Pages (769-780)

Jian Lou, Yue Hu, Min-dan Wu, Luan-qing Che, Yin-fang Wu, Yun Zhao, Bao-ping Tian, Zheng-qiang Bao, Chen Zhu, Yan-ping Wu, Lu-lu He, Chun-xue Bai, Jian Zhou, Song-min Ying, Wen Li, Zhi-hua Chen, Da-xin Chen, Anthony Dorling, Hua-hao Shen

Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating ﬁbrosis-related factors Pages (781-789)

Fang Zhang, Yue Zhou, Xiao Yang, Ai-zhen Xiong, Zheng-tao Wang, Li Yang

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1 Pages (790-800)

Nai-jun Miao, Hong-yan Xie, Dan Xu, Jian-yong Yin, Yan-zhe Wang, Bao Wang, Fan Yin, Zhuan-li Zhou, Qian Cheng, Pan-pan Chen, Li Zhou, Hong Xue, Wei Zhang, Xiao-xia Wang, Jun Liu, Li-min Lu

Paeoniflorin-6′-O-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2- NF-κB signaling: comparison with biological agents Pages (801-813)

Jin-ling Shu, Xian-zheng Zhang, Le Han, Feng Zhang, Yu-jing Wu, Xiao-yu Tang, Chen Wang, Yu Tai, Qing-tong Wang, Jing-yu Chen, Yan Chang, Hua-xun Wu, Ling-ling Zhang, Wei Wei

THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism Pages (814-822)

Zhu-Jun Cheng, Du-Ling Miao, Qiu-Yun Su, Xiao-Li Tang, Xiao-Lei Wang, Li-Bin Deng, Hui-Dong Shi, Hong-Bo Xin

C11, a novel ﬁbroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis Pages (823-832)

Zhuo Chen, Lin-jiang Tong, Bai-you Tang, Hong-yan Liu, Xin Wang, Tao Zhang, Xian-wen Cao, Yi Chen, Hong-lin Li, Xu-hong Qian, Yu-fang Xu, Hua Xie, Jian Ding

Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions Pages (833-849)

Olajide E. Olaleye, Wei Niu, Fei-fei Du, Feng-qing Wang, Fang Xu, Salisa Pintusophon, Jun-lan Lu, Jun-ling Yang, Chuan Li

The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations Pages (850–858)

Ting-ting Liu, Teng Yang, Mei-na Gao, Kai-xian Chen, Song Yang, Kun-qian Yu, Hua-liang Jiang

Vol 40, No 6 (June 2019): Acta Pharmacologica Sinica

Article

CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deﬁcits and inhibits reactive astrogliosis in rat ischemic stroke Pages (724-736)

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model Pages (737-745)

Identification and characterization of a series of novel HCN channel inhibitors Pages (746–754)

Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABA_A receptors Pages (755-761)

Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients Pages (762-768)

Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury Pages (769-780)

Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating ﬁbrosis-related factors Pages (781-789)

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1 Pages (790-800)

Paeoniflorin-6′-O-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2- NF-κB signaling: comparison with biological agents Pages (801-813)

THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism Pages (814-822)

C11, a novel ﬁbroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis Pages (823-832)

Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions Pages (833-849)

The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations Pages (850–858)

Review Article

State-of-the-art: functional ﬂuorescent probes for bioimaging and pharmacological research Pages (717-723)

Table of Contents

Cover Image

Vol 40, No 6 (June 2019): Acta Pharmacologica Sinica

Article

CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deﬁcits and inhibits reactive astrogliosis in rat ischemic stroke Pages (724-736)

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model Pages (737-745)

Identification and characterization of a series of novel HCN channel inhibitors Pages (746–754)

Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABAA receptors Pages (755-761)

Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients Pages (762-768)

Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury Pages (769-780)

Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating ﬁbrosis-related factors Pages (781-789)

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1 Pages (790-800)

Paeoniflorin-6′-O-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2- NF-κB signaling: comparison with biological agents Pages (801-813)

THZ1 suppresses human non-small-cell lung cancer cells in vitro through interference with cancer metabolism Pages (814-822)

C11, a novel ﬁbroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis Pages (823-832)

Multiple circulating saponins from intravenous ShenMai inhibit OATP1Bs in vitro: potential joint precipitants of drug interactions Pages (833-849)

The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations Pages (850–858)

Review Article

State-of-the-art: functional ﬂuorescent probes for bioimaging and pharmacological research Pages (717-723)

Table of Contents

Cover Image

Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABA_A receptors Pages (755-761)