Vol 35, No 1 (January 2014): Acta Pharmacologica Sinica

Review

The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy Pages(1-10) Open
Jose JG Marin, Maria J Monte, Alba G Blazquez, Rocio IR Macias, Maria A Serrano, Oscar Briz
Deorphanizing the human transmembrane genome: A landscape of uncharacterized membrane proteins Pages(11-23) Open
Joseph J Babcock, Min Li

Original Article

Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder Pages(24-32)
Zhong-lin Huang, Rui Liu, Xiao-yu Bai, Gang Zhao, Jun-ke Song, Song Wu, Guan-hua Du
Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro Pages(33-40)
Shu-ying Yu, Xia-yan Zhang, Xiao-rong Wang, Dong-min Xu, Lu Chen, Li-hui Zhang, San-hua Fang, Yun-bi Lu, Wei-ping Zhang, Er-qing Wei
Acetazolamide attenuates chemical-stimulated but not thermal-stimulated acute pain in mice Pages(41-47)
Ya-jie Sun, Ying Chen, Chong Pang, Ning Wu, Jin Li
(−)Doxazosin is a necessary component for the hypotensive effect of (±)doxazosin during long-term administration in conscious rats Pages(48-57)
Jing Zhao, De-zhi Kong, Qing Li, Ya-qin Zhen, Miao Wang, Yan Zhao, Dong-kai Wang, Lei-ming Ren
Acute exposure of methylglyoxal leads to activation of KATP channels expressed in HEK293 cells Pages(58-64)
Yang Yang, Anuhya S Konduru, Ningren Cui, Lei Yu, Timothy C Trower, Weiwei Shi, Yun Shi, Chun Jiang
Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease Pages(65-73)
Hu Cai, Zhe Wang, Hai-qing Zhang, Fu-rong Wang, Chun-xiao Yu, Feng-xia Zhang, Ling Gao, Jian Zhang, Jia-jun Zhao
Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro Pages(74-81)
Timo Kirschstein, Chris Protzel, Katrin Porath, Tina Sellmann, Rüdiger Köhling, Oliver W Hakenberg
P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma Pages(82-88)
Zhe-ping Fang, Bei-ge Jiang, Xue-feng Gu, Bin Zhao, Rui-liang Ge, Fa-biao Zhang
Yhhu3813 is a novel selective inhibitor of c-Met Kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cells Pages(89-97)
Chang-xi He, Jing Ai, Wei-qiang Xing, Yi Chen, Hao-tian Zhang, Min Huang, You-hong Hu, Jian Ding, Mei-yu Geng
CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells Pages(98-112)
Monika Pawłowska, Ewa Augustin, Zofia Mazerska
Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways Pages(113-123)
Chuan-bin Yang, Wei-jing Pei, Jia Zhao, Yuan-yuan Cheng, Xiao-hui Zheng, Jian-hui Rong
Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice Pages(124-134)
Wei Yan, Ting-yu Wang, Qi-ming Fan, Lin Du, Jia-ke Xu, Zan-jing Zhai, Hao-wei Li, Ting-ting Tang
Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux Pages(135-142)
Dan Jiang, Kai Chen, Xuan Lu, Hong-jian Gao, Zheng-hong Qin, Fang Lin
Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation-induced aging in mice Pages(143-150)
Cui Chen, Xin-yi Mu, Yue Zhou, Ke Shun, Shan Geng, Jun Liu, Jian-wei Wang, Jie Chen, Tin-yu Li, Ya-ping Wang
3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis Pages(151-160)
Bao-qin Cai, Hai-xiao Jin, Xiao-jun Yan, Peng Zhu, Gui-xiang Hu