Vol 31, No 11 (November 2010): Acta Pharmacologica Sinica

Research Highlight

The Achilles heel of γ-secretase: can we contain Alzheimer's disease by reducing synthesis of β-amyloid? Pages:1407-1408
Alexei Verkhratsky, José Julio Rodríguez

Review

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets Pages:1409-1420
Tamara Severi, Hannah van Malenstein, Chris Verslype, Jos F van Pelt

Original Article

The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice Pages:1421-1430
Yuan Hong, Wei Yan, Sheng Chen, Chong-ran Sun, Jian-min Zhang
Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice Pages:1431-1437
Ying-xia Gong, Wen-ting Shou, Bo Feng, Wei-ping Zhang, Hui-juan Wang, Hiroshi Ohtsu, Zhong Chen
Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C Pages:1438-1446
An-tao Luo, Hong-yan Luo, Xin-wu Hu, Lin-lin Gao, Hua-min Liang, Ming Tang, Jürgen Hescheler
Rimonabant inhibits TNF-α-induced endothelial IL-6 secretion via CB1 receptor and cAMP-dependent protein kinase pathway Pages:1447-1453
Nan-lan Huang, Jyh-ming Juang, Yi-ho Wang, Chia-hsiang Hsueh, Yao-jen Liang, Jiunn-lee Lin, Chia-ti Tsai, Ling-ping Lai
Implantation of bFGF-treated islet progenitor cells ameliorates streptozotocin-induced diabetes in rats Pages:1454-1463
Ge Li, Li-song Huang, Ming-hong Jiang, Hui-ling Wu, Jing Chen, Yin Huang, Yan Shen, SaiYin He-Xi-Ge, Wei-wei Fan, Zhi-qiang Lu, Da-ru Lu
No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families Pages:1464-1469
Jin-bo Yu, Yao-hua Ke, Jin-wei He, Hao Zhang, Wei-wei Hu, Yun-qiu Hu, Miao Li, Yu-juan Liu, Jie-mei Gu, Wen-zhen Fu, Gao Gao, Hua Yue, Wen-jin Xiao, Zhen-lin Zhang
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice Pages:1470-1477
Xiao-dong Zhang, Jian-wei Yan, Gui-rui Yan, Xiao-yun Sun, Jun Ji, Yi-ming Li, You-hong Hu, He-yao Wang
Differentiation of embryonic stem cells into hepatocytes that coexpress coagulation factors VIII and IX Pages:1478-1486
Jun Cao, Chang-zhen Shang, Li-hong Lü, De-chuan Qiu, Meng Ren, Ya-jin Chen, Jun Min
Selection of reliable reference genes for gene expression study in nasopharyngeal carcinoma Pages:1487-1494
Yi Guo, Jia-xin Chen, Shu Yang, Xu-ping Fu, Zheng Zhang, Ke-he Chen, Yan Huang, Yao Li, Yi Xie, Yu-min Mao
Effect of acetaminophen (paracetamol) on human osteosarcoma cell line MG63 Pages:1495-1499
Lourdes Díaz-Rodríguez, Olga García-Martínez, Manuel Arroyo-Morales, Belén Rubio-Ruiz, Concepción Ruiz
Population pharmacokinetics of rhTNFR-Fc in healthy Chinese volunteers and in Chinese patients with Ankylosing spondylitis Pages:1500-1507
Yi Fang, Lu-jin Li, Rui Wang, Feng Huang, Hai-feng Song, Zhong-ming Tang, Yu-zhen Li, Hua-shi Guan, Qing-shan Zheng
HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats Pages:1508-1514
Li-hong Long, Peng-fei Wu, Xiang-long Chen, Zui Zhang, Yu Chen, Yi-yong Li, You Jin, Jian-guo Chen, Fang Wang
Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors Pages:1515-1522
Zhao Yan, Zhong-ling Zhu, Hua-qing Wang, Wei Li, Ya-xian Mi, Chang-xiao Liu