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Non-coding RNAs as biomarkers for acute myocardial infarction

	author = {Chen WANG and Qing JING},
	title = {Non-coding RNAs as biomarkers for acute myocardial infarction},
	journal = {Acta Pharmacologica Sinica},
	volume = {39},
	number = {7},
	year = {2018},
	keywords = {},
	abstract = {Acute myocardial infarction (AMI) is a main threat to human lives worldwide.  Early and accurate diagnoses warrant immediate medical care, which would reduce mortality and improve prognoses.  Circulating non-coding RNAs have been demonstrated to serve as competent biomarkers for various diseases.  Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction.  Here, we summarized recent findings on non-coding RNAs as biomarkers for early diagnosis of ST-segment elevation myocardial infarction and for disease monitoring of myocardial infarction.  In addition, the prognostic potential of non-coding RNAs in patients treated with percutaneous coronary intervention was also described.  We also include studies based on biobanks, and build a miRNA release spectrum after AMI, which provides quantitative and time-lapse monitoring of AMI progress.  With this spectrum, we are able to customize personal medical care, which prevents further damage.  By constructing a network of circulating non-coding RNAs with high specificity and sensitivity, detailed diagnostic information was provided for personalized medicine.  Unveiling the roles and kinetics of circulating non-coding RNAs may lead to a revolution in clinical diagnosis.},
	issn = {1745-7254},	url = {}