TY - JOUR AU - BALLARIN Beatrice AU - TYMIANSKI Michael PY - 2018 TI - Discovery and development of NA-1 for the treatment of acute ischemic stroke JF - Acta Pharmacologica Sinica; Vol 39, No 5 (May 2018): Acta Pharmacologica Sinica (Special Issue on Frontier in Medical Research and Drug Development) Y2 - 2018 KW - N2 - Abstract Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. In this review we describe its signaling cascade, the target of its therapeutic intervention and its translation from bench to clinical trial. UR - http://www.chinaphar.com/article/view/9769