TY - JOUR AU - HE Bin AU - HU Hai-yan AU - TAN Tao AU - WANG Hong AU - SUN Kao-xiang AU - LI Ya-ping AU - ZHANG Zhi-wen PY - 2017 TI - IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice JF - Acta Pharmacologica Sinica; Vol 39, No 1 (January 2018): Acta Pharmacologica Sinica Y2 - 2017 KW - N2 - Abstract Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer. UR - http://www.chinaphar.com/article/view/9711