@article{APS9711,
author = {Bin HE and Hai-yan HU and Tao TAN and Hong WANG and Kao-xiang SUN and Ya-ping LI and Zhi-wen ZHANG},
title = {IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice},
journal = {Acta Pharmacologica Sinica},
volume = {39},
number = {1},
year = {2017},
keywords = {},
abstract = {Abstract
Cancer metastasis is responsible for over 90% of breast cancer-related deaths, and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PTT applications in treatment of metastatic breast cancer.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9711}
}