TY - JOUR AU - WANG Jie AU - YAN Dan-dan AU - HOU Xu-hong AU - BAO Yu-qian AU - HU Cheng AU - ZHANG Zhen-lin AU - JIA Wei-ping PY - 2017 TI - Association of bone turnover markers with glucose metabolism in Chinese population JF - Acta Pharmacologica Sinica; Vol 38, No 12 (December 2017): Acta Pharmacologica Sinica Y2 - 2017 KW - N2 - Abstract The association between type 2 diabetes (T2DM) and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose metabolism in Chinese population, in which 919 males and 4171 postmenopausal females in a region of Shanghai were recruited. Anthropometric and biochemical traits related to glucose and bone metabolism were analyzed. Participants were classified according to their glucose tolerance as normal glucose tolerance (NGT), impaired glucose regulation (IGR) or T2DM. Males and females were analyzed separately, and then associations between bone turnover markers (BTMs) and glucose metabolism were evaluated. The results showed that in females, the serum levels of N-terminal osteocalcin (N-MID), N-terminal procollagen of type I collagen (PINP) and β-cross-linked C-telopeptide of type I collagen (β-CTX) were significantly decreased in the T2DM group compared to the NGT group ( P P =0.0001) was significantly associated with T2DM in females. In females, N-MID was associated with insulin sensitivity and HOMA-β. PINP was significantly associated with HOMA-β, GUTT-ISI, Stumvoll first-phase insulin secretion index (STU-1) and Stumvoll second-phase insulin secretion index (STU-2), but β-CTX was associated only with HOMA-β (β±SE: 0.1331±0.0311; P=1.95×10 -5 ) and GUTT-ISI (β±SE: 0.0727±0.0229; P =0.0015). In males, N-MID was significantly correlated with HOMA-β (β±SE: 0.3439±0.0633; P=7.75×10 -8 ), GUTT-ISI (β±SE: 0.1601±0.0531; P =0.0027) and STU-1 (β±SE: 0.2529±0.1033; P =0.0146). Significant associations were also detected between β-CTX and HOMA-β (β±SE: 0.2736±0.0812; P =0.0009). This study reveals that BTMs are highly associated with T2DM, insulin sensitivity and beta cell function in both Chinese males and postmenopausal females. UR - http://www.chinaphar.com/article/view/9689