TY - JOUR AU - ZHANG Shu-qin AU - YANG Zhe AU - CAI Xiao-li AU - ZHAO Man AU - SUN Ming-ming AU - LI Jiong AU - FENG Guo-xing AU - FENG Jin-yan AU - YE Li-hong AU - NIU Jun-qi AU - ZHANG Xiao-dong PY - 2017 TI - miR-511 promotes the proliferation of human hepatoma cells by targeting the 3’UTR of B cell translocation gene 1 (BTG1) mRNA JF - Acta Pharmacologica Sinica; Vol 38, No 8 (August 2017): Acta Pharmacologica Sinica Y2 - 2017 KW - N2 - Aberrant expression of miR-511 is involved in the development of cancer, but the role of miR-511 in hepatocellular carcinoma (HCC) is not well documented. In this study, we explored the molecular mechanisms of miR-511 in hepatocarcinogenesis. Our results of bioinformatics analysis suggested that B cell translocation gene 1 (BTG1), a member of anti-proliferative gene family, was one of the putative targets of miR-511. The expression levels of miR-511 were significantly higher in 30 clinical HCC tissues than in corresponding peritumor tissues, and were negatively correlated with those of BTG1 in the HCC tissues ( r =-0.6105, P 1 phase arrest, which was rescued by overexpression of BTG1. Furthermore, overexpression of miR-511 promoted the proliferation of the hepatoma cells, which was rescued by overexpression of BTG1. Conversely, knockdown of miR-511 inhibited cell proliferation, which was reversed by knockdown of BTG1. In conclusion, miR-511 promotes the proliferation of human hepatoma cells in vitro by targeting the 3’UTR of BTG1 mRNA. UR - http://www.chinaphar.com/article/view/9651