@article{APS9390,
author = {Ze-yu Zhong and Bin-bin Sun and Nan Shu and Qiu-shi Xie and Xian-ge Tang and Zhao-li Ling and Fan Wang and Kai-jing Zhao and Ping Xu and Mian Zhang and Ying Li and Yang Chen and Li Liu and Lun-zhu Xia and Xiao-dong Liu},
title = {Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal β-glucuronidase activity},
journal = {Acta Pharmacologica Sinica},
volume = {37},
number = {7},
year = {2017},
keywords = {},
abstract = {Aim: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy). In this study we investigated whether co-administration of ciprofloxacin affected the pharmacokinetics of diclofenac and diclofenac-induced enteropathy in rats.
Methods: The pharmacokinetics of diclofenac was assessed in rats after receiving diclofenac (10 mg/kg, ig, or 5 mg/kg, iv), with or without ciprofloxacin (20 mg/kg, ig) co-administered. After receiving 6 oral doses or 15 intravenous doses of diclofenac, the rats were sacrificed, and small intestine was removed to examine diclofenac-induced enteropathy. β-Glucuronidase activity in intestinal content, bovine liver and E coli was evaluated.
Results: Following oral or intravenous administration, the pharmacokinetic profile of diclofenac displayed typical enterohepatic circulation, and co-administration of ciprofloxacin abolished the enterohepatic circulation, resulted in significant reduction in the plasma content of diclofenac. In control rats, β-glucuronidase activity in small intestinal content was region-dependent: proximal intestine},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9390}
}