@article{APS9172,
author = {Zhu-Bin Lei and Xu-Jie Fuu and Zhao-Tong Lu and Bao-Cheng Wang and Xian-Lian Liu and Nai-Zhen You},
title = {Effect of estradiol on chemokine receptor CXCR2 expression in rats: implications for atherosclerosis},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {7},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of 17beta-estradiol on expression of chemokine receptor CXCR2 in monocytes in vivo.
METHODS: Expressions of chemokine receptor CXCR2 mRNA and protein were measured by RT-PCR and flow cytometry, respectively.
RESULTS: In both ovary-intact and ovariectomized (OVX) rats, CXCR2 protein and mRNA expression were significantly increased in rats fed with a high-cholesterol diet for 6 weeks. The cholesterol-induced increases in CXCR2 protein and mRNA expression were significantly attenuated in OVX rats injected with estradiol-17beta (17beta-E2) (5 and 20 microg x kg(-1) x d(-1)). In normal diet rats, CXCR2 protein and mRNA expression were increased in OVX rats compared with ovary-intact rats, and this increase was prevented by 17beta-E2.
CONCLUSION: Both basal and hypercholesterolemia-induced increases in chemokine receptor CXCR2 are modulated by physiological concentrations of estradiol.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9172}
}