@article{APS9167,
author = {Shan Wang and Jie-Bo Mi and Yuan-Zong Li and Wen-Bao Chang and Yun-Xiang Si and Min-Zheng Zhao and Yun-Kun Zhao and Li-Ya Zhu and Guang Xu},
title = {Pharmacokinetics and tissue distribution of iv injection of polyphase liposome-encapsulated cisplatin (KM-1) in rats.},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM: The pharmacokinetics and biodistribution of cisplatin encapsulated in polyphase liposome (KM-1) were compared with those of free drug in rats. METHODS: The platinum levels in serum and normal organs, after a single dose of iv injection of free or encapsulated cisplatin to rats, were determined by induced coupled plasma atomic emission spectrometry. RESULTS: Serum platinum concentration-time curve after a single iv dose of KM-1 4.5 mg/kg in rats was fitted with an open three-compartment model. The pharmacokinetic parameters were as follows: Vc=0.10 L/kg, T1/2pai=0.3 h, T1/2alpha=3.5 h, T1/2beta=2.7 h, AUC=265 mg.h.L(-1), and CL(s) =0.02 g.L.h(-1). KM-1 was cleared from the circulation much more slowly than free cisplatin. Liver and spleen had the highest concentration of platinum after KM-1 treatment. CONCLUSION: KM-1 remained in the bloodstream longer than its free drug, and was taken mainly by the reticuloendothelial system.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9167}
}