How to cite item

Group I mGluR ligands fail to affect 6-hydroxydopamine- induced death and glutamate release of PC12 cells

   
@article{APS9165,
	author = {Hao Li and Jian-Hua Ding and Gang Hu},
	title = {Group I mGluR ligands fail to affect 6-hydroxydopamine- induced death and glutamate release of PC12 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {7},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of group I metabotropic glutamate receptor (mGluR) ligands on 6-hydroxydopamine (6-OHDA)-induced death and glutamate release of PC12 cells. 
METHODS: PC12 cells were exposed to 100 micromol/L of group I mGluR agonist (RS)-3,5-dihydroxy-phenylglycine (DHPG) or antagonist DL-2-amino-3-phosphonopropionic acid (DL-AP3) 1 h before addition of 6-OHDA 100 micromol/L. After incubation for 24 h, morphological alterations were observed with microscope, DNA fragmentation was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method, cytotoxicity was measured by MTT assay, and glutamate release was assayed by high performance liquid chromatography. 
RESULTS: 6-OHDA decreased cell viability (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9165}
}