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High glucose enhance expression of matrix metalloproteinase-2 in smooth muscle cells.

   
@article{APS9152,
	author = {Feng Hao and Jin-De Yu},
	title = {High glucose enhance expression of matrix metalloproteinase-2 in smooth muscle cells.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate the effects of high glucose on expression of matrix metalloproteinase-2 (MMP-2) in rat aortic smooth muscle cells and the influence of matrix remodeling on atherogenesis in diabetic patients. METHODS: The smooth muscle cells were cultured from the thoracic aorta of Sprague-Dawley (SD) rat. MMP-2 mRNA was determined by reverse transcriptase-polymerase chain reaction (RT-PCR), MMP-2 protein was measured by Western blotting, and MMP-2 activity in conditioned medium was observed by zymography. RESULTS: In comparison with the control, there was no difference in the expression of MMP-2 when glucose concentration was 1 g/L, whereas MMP-2 activity in smooth muscle cells was significantly increased by the glucose 5 g/L (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9152}
}