%0 Journal Article %T Reliability of phototoxic tests of fluoroquinolones in vitro. %A Zhang Ting %A Li Jun-Ling %A Ma Xiao-Chao %A Xin Jian %A Tu Zeng-Hong %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Reliability of phototoxic tests of fluoroquinolones in vitro. %K %X AIM: To make sure the reliability of phototoxic tests in vitro by comparing the phototoxic potential of 4 fluoroquinolones (FQ). METHODS: Lomefloxacin (LFLX), sparfloxacin (SPFX), ciprofloxacin (CPFX), and norfloxacin (NFLX) were tested by Wistar rat phototoxic test and Balb/c mouse phototoxic test in vivo, and Chinese hamster V79 cell micronucleus test and NIH 3T3 MTT test in vitro under the different condition of UVA irradiation. RESULTS: In all experiments, LFLX and SPFX showed higher phototoxic potential compared with the control (P<0.01 vs 1 % CMC), CPFX was mild (P<0.05 vs physiological saline), NFLX did not show phototoxicity in vivo, however at a higher concentration (10 micromol/L) in vitro, it also induced phototoxicity as other FQ. CONCLUSION: There are good correlations between phototoxic tests in vivo and in vitro. These results ensure the validation of phototoxic tests in vitro. %U http://www.chinaphar.com/article/view/9128 %V 24 %N 5 %P 453-459 %@ 1745-7254