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Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice.

   
@article{APS9121,
	author = {Bing Shen and Chun-Ling Ye and Kai-He Ye and Jian-Jun Liu and Peng Sun and Jia-Hua Jiang},
	title = {Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice.},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate the mechanism of the enhanced endothelium-dependent vasodilatation in thoracic aorta of the early stage streptozotocin (STZ)-induced diabetic C57BL/6J mice. METHODS: Radioimmunity was used to detect the metabolite of prostaglandin I2 (PGI2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), in the blood serum. Vascular muscle tension and phenylephrine (PE)-induced rhythmic activity in the isolated thoracic aorta of mice were also compared. RESULTS: 6-Keto-PGF1 alpha in the serum was significantly higher in STZ-induced diabetic mice than age-matched controls [(1.8+/-1.0) microg./L vs (0.5+/-0.3) microg/L, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9121}
}