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Effects of artemisinin on action potentials from C-type nodose ganglion neurons

   
@article{APS9120,
	author = {Guo-Fen Qiao and Bao-Feng Yang and Wen-Han Li and Bai-Yan Li},
	title = {Effects of artemisinin on action potentials from C-type nodose ganglion neurons},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {AIM: To investigate the effects of artemisinin (Art) on the action potentials (AP) recorded from identified C-type nodose neurons and study its anti-arrhythmic and anesthetic mechanisms. 
METHODS:Neonatal and adult rats were selected for the preparation of isolated nodose ganglia neurons (NGN) and nodose ganglion-vagus slice preparation. Somatic AP were recorded from both isolated and slice NGN using whole-cell patch technique. Conduction velocity (CV) was measured using slice preparation. The effects of Art on AP were evaluated with the reference to ketamine. 
RESULTS: Effects of Art on AP were that: (1) AP depolarizing profiles were inhibited without changing resting membrane potential (RMP). The peak of AP (AP(peak)) and upstroke velocity (UV(APD50) and UV(max)) decreased markedly (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/9120}
}