%0 Journal Article %T Hypoglycemic activity of ginseng glycopeptide. %A Wang Ben-Xiang %A Zhou Qiu-Li %A Yang Ming %A Wang Yan %A Cui Zhi-Yong %A Liu Yong-Qiang %A Ikejima Takashi %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Hypoglycemic activity of ginseng glycopeptide. %K %X AIM: To study the hypoglycemic activity of ginseng glycopeptide (GGP). METHODS: Normal mice or rabbits and alloxan or streptozotocin-induced hyperglycemic rats or mice were used in the study. Blood glucose and liver glycogen levels of the experimental animals during the trial period were analyzed by spectrophotometry with O-toluidine and iodine reagents, respectively. RESULTS: Significant decreases in blood glucose and liver glycogen levels were induced in a dose-dependent manner after administration of GGP 50, 100, or 200 mg/kg injected ip or sc to normal mice and injected im 30 or 60 mg/kg to normal rabbits. The hypoglycemic activity of GGP lasted for about 16 h, and were examined in both normal animals and hyperglycemic animals. CONCLUSION: GGP injection induced the pronounced decreases in blood glucose and liver glycogen levels in both normal and hyperglycemic animals. %U http://www.chinaphar.com/article/view/9022 %V 24 %N 1 %P 50-54 %@ 1745-7254