@article{APS9011,
author = {Yi Zhang and Kui-Xing Zhang and Gu-Liang Wang and Wei Huang and Ding-Liang Zhu},
title = {Angiotensin II type 2 receptor gene polymorphisms and essential hypertension},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM: To identify the genetic variants of angiotensin II type 2 receptor (AT2R) gene in a Chinese population and to determine whether the AT2R gene polymorphisms are associated with essential hypertension (EH).
METHODS: The detection of single nucleotide polymorphisms (SNPs) was performed in 19 subjects by a direct DNA sequencing. Two hundred fifty patients with EH and 250 nomortensive controls were included in the study to assess the contribution of polymorphism of AT2R gene to hypertension.
RESULTS: We identified 9 SNPs in the promoter, intron, exons and 3' untranslated region (3'UTR) of AT2R gene; among them 5 SNPs were novel molecular variants. A case-control study using a most frequent SNP (1334T/C) in the promoter region, showed a significant increase in allele frequency of C1334 in male hypertensive subjects (17.5 % vs 10.3 % for normotensive subjects, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/9011}
}