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Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons

   
@article{APS8957,
	author = {Guang-Qin Zhang and Xue-Mei Hao and Shi-Zhong Chen and Pei-Ai Zhou and He-Ping Cheng and Cai-Hong Wu},
	title = {Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons},
	journal = {Acta Pharmacologica Sinica},
	volume = {24},
	number = {12},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the blockade of paeoniflorin (Pae) on I(Na) in the acutely isolated hippocampus neurons of mice. 
METHODS: The whole-cell patch clamp technique was used. 
RESULTS: Pae inhibited I(Na) in frequency-dependent and concentration-dependent manners, with an IC50 of 271 micromol/L. Pae 0.3 mmol/L shifted the activation potential of the maximal I(Na) from -40 mV to -30 mV, shifted the steady-state activation and inactivation curves toward more positive and negative potentials by 10.8 mV, and 18.2 mV, respectively, and postponed the recovery of I(Na) inactivation state from (4.2+/-0.7) ms to (9.8+/-1.2) ms. 
CONCLUSION: Pae inhibited I(Na) in mouse hippocampus neurons.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8957}
}