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Delay of metabolism rate of ciclosporin by simvastatin in 7 Chinese healthy men.

   
@article{APS8956,
	author = {Feng Xu and Zhao-Hui Wu and Zhong-Yi Zhang and Heng-Qin Zou},
	title = {Delay of metabolism rate of ciclosporin by simvastatin in 7 Chinese healthy men.},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of simvastatin (Sim) on pharmacokinetics of ciclosporin (Cic). METHODS: Seven healthy young volunteers took Cic 100 mg alone or in combination with Sim 10 mg in a randomized crossover study. The Cic concentrations in blood were determined by specific fluorescence polarization immunoassay. Data were analyzed with 3P87 program. RESULTS: The blood concentration-time curve was fitted to open 2-compartment model, and the pharmacokinetic parameters of Cic alone and Cic + Sim were: Cmax (646 +/- 94) and (698 +/- 340) micrograms.L-1; Tmax (1.12 +/- 0.13) and (1.13 +/- 0.21) h; AUC (2.3 +/- 0.4) and (2.6 +/- 1.2) mg.h.L-1; T1/2 beta (12 +/- 6) and (23 +/- 8) h (P < 0.05). CONCLUSION: Sim delays the metabolism rate of Cic when they are given simutaneously.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8956}
}