@article{APS8953,
author = {Wen Cao and Hai-Tong Zhuo and Gang Chen and Shu-Sen Ling},
title = {Pharmacokinetics of theophylline metabolites in 8 Chinese patients.},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To study theophylline metabolites pharmacokinetics in patients after a therapeutic dose. METHODS: Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6.6 mumol.kg-1). The plasma concentrations of theophylline and its 4 metabolites: 1,3-dimethyluric acid (DMUA), 3-methylxanthine (3-MX), 1-methyluric acid (MUA), and the intermediate 1-methylxanthine (1-MX) were monitored by HPLC throughout 24 h. RESULTS: The plasma concentration of DMUA was the highest one among the 4 metabolites. 3-MX showed the slowest elimination rate. The plasma concentration of 1-MX throughout a 24-h period showed that there was a picking up of 1-MX (from 0.04 mumol.L-1 to 1.05 mumol.L-1) in the next morning. CONCLUSION: The formation of DMUA was the main metabolites. During night there was an accumulation of 1-MX.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8953}
}