@article{APS8951,
author = {Carla Elisa Borin Goncalves and Ligiane Vieira Tokano-ramos and Renata Correa Pasccoto and Ciomar Aparecida Bersani-Amado},
title = {Intradermal irritation of dental bleaching agents in rats.},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To evaluate the irritative potential of three dental bleaching agents (hydrogen oxide, carbopol, and carbamide peroxide). METHODS: In rats, Evans blue (2.5%, 1 mL.L-1) was injected i.v. and later each test solution was injected intradermally on the back. After the concentration of the dye in the stained skin area was determined by spectrophotometric analysis. RESULTS: All the dental bleaching agents caused increase of vascular permeability and the intensity varied with the time. CONCLUSION: Dental bleach agents had a great potential for irritating soft tissues.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8951}
}