@article{APS8932,
author = {Jian-Xiong Chen and Wei-Zhou Chen and Hong-Lin Huang and Lin-Xi Chen and Zhi-Zhong Xie and Bin-Yang Zhu},
title = {Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the protective effects of Ginkgo biloba extract (GbE) against endothelial cell damage induced by lysophosphatidylcholine (LPC).
METHODS: The vasorelaxation response to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aorta. Lipid peroxidation products were determined by measuring thiobarbituric acid reactive substance.
RESULTS: GbE attenuated the inhibition of vasorelaxation response to ACh and prevented the LPC-induced increase of malondialdehyde (MDA) content both in thoracic aortae. GbE prevented the leakage of LDH and the increase of MDA content in cultured endothelial cells in a concentration-dependent manner. GbE also markedly increased epoprostenol level in cultured endothelial cells treated with LPC. CONCLUSION: GbE protected endothelial cells against LPC-induced damage due to reduction in lipid peroxidation and facilitation of synthesis and/or release of epoprostenol.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8932}
}