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Effects of verapamil on down-regulation of norepinephrine-induced beta adrenoceptors in cultured rat cardiomyocytes.

   
@article{APS8909,
	author = {Biao Xu and Suo-Long Zhang and Ri-Xin Chen},
	title = {Effects of verapamil on down-regulation of norepinephrine-induced beta adrenoceptors in cultured rat cardiomyocytes.},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {AIM: To determine whether verapamil (Ver) inhibits norepinephrine (NE)-induced beta adrenoceptors down-regulation in cultured rat cardiomyocytes. METHODS: [3H]-Dihydroalprenolol (DHA) radiobinding assay was used to measure beta adrenoceptor density, fluorescent indicator Fura 2-AM was used to estimate levels of free cytosolic calcium ([Ca2+]i). RESULTS: Ver reduced [Ca2+]i and increased beta adrenoceptor density, NE increased [Ca2+]i and reduced beta adrenoceptor density of cultured cardiomyocytes, these effects were time and concentration dependent. Ver inhibited the above effects of NE. CONCLUSIONS: Ver increased beta adrenoceptor density and inhibited NE-induced beta adrenoceptor down-regulation of cardiomyocytes.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8909}
}