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Effects of norepinephrine and isopentenyladenosine on Na+/Ca2+ exchange currents in isolated guinea pig ventricular myocytes.

   
@article{APS8907,
	author = {Wen Dun and Bo-Wei Wu and Rong-Rui Zhao},
	title = {Effects of norepinephrine and isopentenyladenosine on Na+/Ca2+ exchange currents in isolated guinea pig ventricular myocytes.},
	journal = {Acta Pharmacologica Sinica},
	volume = {19},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of norepinephrine (NE) and isopentenyladenosine (Iso) on Na+/Ca2+ exchange currents and the receptor mechanism. METHODS: The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular myocytes was measured using whole-cell voltage-clamp techniques with a ramp pulse protocol. RESULTS: At potential of +50 mV, NE 0.005, 0.05, and 5 mumol.L-1 increased the Ni(2+)-sensitive current by 29% +/- 9%, 72% +/- 11%, and 124% +/- 31.4%, respectively; Iso 1.5, 150, and 1500 nmol.L-1 caused increases in the Ni(2+)-sensitive current by 2.8% +/- 2.8%, 56% +/- 13%, and 102% +/- 12%, respectively. Propranolol 10 mumol.L-1 completely inhibited the current changes induced by NE and Iso while phentolamine 50 mumol.L-1 showed no effects. CONCLUSION: NE and Iso increased the Na+/Ca2+ exchange currents via stimulation of cardiac beta-adrenoceptor.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/8907}
}