@article{APS8887,
author = {Peng-Chong Liu and Zeng-Jin Yang and Mei-Hong Qiu and Ling-Mei Zhang and Feng-Yan Sun},
title = {Induction of CRMP-4 in striatum of adult rat after transient brain ischemia},
journal = {Acta Pharmacologica Sinica},
volume = {24},
number = {12},
year = {2016},
keywords = {},
abstract = {AIM: To study the expression of collapsing response mediated protein-4 (CRMP-4) and nestin in the ischemic adult rat brain following transient brain ischemia.
METHODS: Brain ischemia was induced by transient left middle cerebral artery occlusion (MCAO) for 60 min in adult rats. The expression of CRMP-4, nestin and bromodeoxyuridine (BrdU) was analyzed by immunohistochemical method. The co-localization of CRMP-4 and nestin or BrdU was analyzed by double staining combined with confocal laser scanning microscopy.
RESULTS: CRMP-4, a marker of immature neuron, could be expressed in the ipsilateral striatum and cerebral cortex at 1st and 2nd week after the ischemia-reperfusion; nestin, a marker of neural stem cell, occurred in above regions from several hours to 2 weeks. CRMP-4 costained with nestin and with BrdU incorporation.
CONCLUSION: Neural stem cells may present in the striatum and cerebral cortex of adult rat and can be triggered to differentiate into newborn neuron there by ischemic brain trauma.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8887}
}