@article{APS8877,
author = {Yi Zhang and Yong-Chang Hao and Li-Lin Song and Shu-Mei Guo and Shuang-Zhen Gu and Shen-Gui Lu},
title = {Effects of sex hormones on action potential and contraction of guinea pig papillary muscle},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of sex hormones, estradiol (Est), progesterone (Pro) and testosterone (Tes) on the action potential (AP) and contraction of guinea pig papillary muscle.
METHODS: Using conventional glass microelectrode and mechanical recording of myocardial contraction.
RESULTS: Est slowed down the maximal rate of rise of phase 0 (Vmax) of AP at low concentration (1 mumol.L-1). At 10 mumol.L-1 and above, Est also prolonged AP duration (APD50 and APD90), effective refractory period (ERP) and decreased the maximal isometric tension (Pmax) and velocity of tension development (dT/dt) of contraction. Tes (100 mumol.L-1 - 1 mmol.L-1) prolonged APD90 and ERP with decreased Pmax and dT/dt. But Pro (1 mumol.L-1 - 1 mmol.L-1) had no effects on both AP and contraction.
CONCLUSION: Est prolonged AP and depressed contraction of guinea pig papillary muscle.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8877}
}