TY  - JOUR
AU  - Gu Chang-Hong
AU  - Yuan Bo-Jun
AU  - Lu Guo-Cai
AU  - Dai Zu-Rui
AU  - Liu Jun-Ping
AU  - Zhang Shu-Ying
AU  - Zhang Pu
AU  - Jiang Chun-Lei
PY  - 2016
TI  - Long-term toxicity of modified recombinant human tumor necrosis factor in Macaca mulatta
JF  - Acta Pharmacologica Sinica; Vol 19, No 1 (January 1998): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - AIM: To study the long-term toxicity of modified recombinant human tumor necrosis factor (rhTNF-NC) in Macaca mulatta compared with recombinant human tumor necrosis factor (rhTNF).   METHODS: rhTNF-NC 93, 9.3 GU/m2, and rhTNF 62 GU/m2 were injected i.v. daily to 16 Macaca mulatta for 1 month and 10 d, respectively. Hematologic, chemical, urinalysis values, ECG, specific antibody, bone marrow, and pathologic profile of organs were measured.   RESULTS: No more adverse effects of rhTNF-NC were found in spite of anorexia in 4 monkeys and palpebral edema in 2 monkeys of 93 GU/m2 group. Besides, in rhTNF group, the injury of liver and kidneys, the decrease of erythron, the phlebitis, and thrombosis at injection site occurred. Both drugs caused the production of specific antibody.   CONCLUSION: No serious adverse effects of rhTNF-NC were found in Macaca mulatta. The toxicity of rhTNF-NC was much lower than that of rhTNF.
UR  - http://www.chinaphar.com/article/view/8863