@article{APS8847,
author = {Jin-Ming Li and Gui-Ying Cui and Dong-Ju Liu and Hong Cui and Tian-Hui Chang and Yu-Ping Wang and Ke-Yi Zhang},
title = {Effects of N-methyl berbamine on delayed outward potassium current in isolated rat hepatocytes},
journal = {Acta Pharmacologica Sinica},
volume = {19},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of N-methyl berbamine (NMB) on the delayed outward potassium currents (Ik) in isolated rat hepatocytes.
METHODS: With patch-clamp techniques and whole-cell recording method, holding potential -50 mV, command potential +30 to +140 mV, duration 900 ms.
RESULTS: NMB reduced Ik in a concentration-dependent manner. When the concentrations of NMB were 20, 50, 400 nmol.L-1 and 50 mumol.L-1, the amplitude values of Ik were decreased to 3.6 +/- 0.4 (P > 0.05), 2.1 +/- 1.6 (P > 0.05), 3.7 +/- 1.6 (P < 0.05), 2.3 +/- 1.3 nA (P < 0.01) from 4.4 +/- 1.0 (n = 4), 2.5 +/- 1.8 (n = 4), 5.8 +/- 2.1 (n = 5), 4.6 +/- 1.3 (n = 6) nA of control, respectively. The inhibitory rates were 10%, 15%, 37%, and 51%, respectively.
CONCLUSION: NMB was a K+ channel inhibitor.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/8847}
}