%0 Journal Article %T Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs %A Zhu Zhu %A Fu Qiang %A Nightingale Charles H %A Zhao Yu-Pei %A Liao Quan %A Wang Hong-Na %A Xue Chang-Qing %A Yang Zhi-Ying %A Li Da-Kui %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs %K %X AIM: To study the pharmacokinetic behavior of 5-fluorouracil (5-FU) in pancreatic juice in dogs and its correlation with 5-FU in plasma, and to evaluate its penetration characteristics. METHODS: After placing a pancreatico-drainage tube, 8 dogs were injected 5-FU 250 mg i.v. Blood and pancreatic samples were collected and the 5-FU concentrations were determined by HPLC. The pharmacokinetic parameters were obtained with statistical analysis. RESULTS: The mean slopes of the terminal phase (K10) in plasma and pancreatic juice were 9.4 h-1 and 10.2 h-1, respectively (P > 0.05). The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model. Its penetration index was 3.39 +/- 2.84. The penetration of 5-FU from blood to pancreatic juice was relatively rapid, demonstrating a consistently higher concentration in pancreatic juice than in plasma. CONCLUSIONS: The elimination phase of 5-FU in plasma was similar to that in pancreatic juice, indicating that they were in the same kinetic compartment. %U http://www.chinaphar.com/article/view/8843 %V 19 %N 1 %P 7-9 %@ 1745-7254