TY - JOUR AU - Huang Cai AU - Qin Yan-Mei AU - Liang Nian-Ci PY - 2016 TI - Effects of aprotinin in platelet aggregation and cytosolic free calcium in swine platelets. JF - Acta Pharmacologica Sinica; Vol 14, No 6 (November 1993): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aprotinin inhibited platelet aggregation induced by thrombin (0.25 U.ml-1) with IC50 200 kIU.ml-1, and inhibited the rise of cytosolic free calcium concentration in platelets stimulated by thrombin (0.1 U.ml-1) in the absence and in the presence of Ca2+ 0.5 mmol.L-1 (IC50 117 and 50 kIU.ml-1, respectively), but had no effect on the amounts of actin and myosin heavy chain associated with cytoskeletons. These suggest that aprotinin is an anti-platelet agent and may exert its action through inhibiting the Ca2+ flux. UR - http://www.chinaphar.com/article/view/8839