TY - JOUR AU - Wu Wei-Zhong AU - Yang Ying-Zhen AU - Jin Pei-Ying AU - Liu Zhong-Yu AU - Zhuang Ya-Chun AU - Zhuang Wen-Yan AU - Gu Ju-Kang AU - Gu Yi-Min PY - 2016 TI - Anti-arrhythmic effects of captopril on coronary occlusion and reperfusion periods in pigs. JF - Acta Pharmacologica Sinica; Vol 14, No 6 (November 1993): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Anti-arrhythmic effects of captopril (Cap) were studied in the anesthetized pigs using a reversible balloon catheter. Results showed that Cap did not exert any influence on the weight percentage of ischemic area to the whole left ventricle, on the levels of serum creatine kinase (CK) and creatine kinase isozyme (CK-MB), nor on the incidence and duration of transient and persistent tachycardia, but reduced the incidence of ventricular fibrillation (2/12, 1/12 in high-dose group pigs treated with Cap 6 mg.kg-1 in the first 10 min, 25 micrograms.kg-1.min-1 in the later 90 min and 12/21, 11/21 in control group treated with normal saline through the occlusion and reperfusion periods, respectively, P < 0.05). It was suggested that Cap did not exhibit direct (or non-specific, if any) effects on anti-arrhythmias. UR - http://www.chinaphar.com/article/view/8827