How to cite item

Opioid, calcium, and adrenergic receptor involvement in protopine analgesia

	author = {Qiang Xu and Rong-Luan Jin and Yun-Yu Wu},
	title = {Opioid, calcium, and adrenergic receptor involvement in protopine analgesia},
	journal = {Acta Pharmacologica Sinica},
	volume = {14},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {The analgesic effect of protopine (Pro), an alkaloid isolated from Papaveraceae, was confirmed by tail-pinch and hot-plate tests when given sc 10-40, and 20-40 inhibited the spontaneous movements of mice. Pro 40 increased the sleeping rate, prolonged the sleeping duration, and shortened the sleeping latency in mice hypnotized by ip pentobarbital sodium 30 Pro 10-40 did not affect the inflammatory reaction induced by xylene and egg white. An icv injection of Pro 20-200 micrograms/mouse showed a remarkable analgesic effect in mice. The icv pretreatment of naloxone 2 micrograms blocked the analgesic effect completely. CaCl2 40 micrograms/mouse (ICV) or methotrexate 10 (ip), an agonist of Ca2+ channel, showed a complete blockade of the analgesia, while nifedipine 100, a blocker of Ca2+ channel, enhanced the analgesic effect. The ip pretreatment of reserpine 4 reduced the Pro analgesia. Phentolamine 10, an alpha-adrenergic blocker, tended to weaken the analgesia, but propranolol 10, a beta-blocker, did not affect it. These results suggest that Pro displays its analgesic effect mainly through the opioid and calcium systems and partly through the adrenergic mechanism.},
	issn = {1745-7254},	url = {}