TY - JOUR AU - Zhou Jun AU - Xuan Bo AU - Li De-Xin PY - 2016 TI - Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats JF - Acta Pharmacologica Sinica; Vol 14, No 2 (March 1993): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The effects of tetrahydroberberine (THB) on ischemic and reperfused myocardium were studied in comparison with verapamil (Ver). In anesthetized rats, THB and its analogues, l-THP and l-SPD, reduced the infarct size after 4 h of left anterior descending coronary artery (LAD) ligation. In Langendorff hearts, in common with Ver, THB 1 and 10 mumol.L-1 markedly decreased the incidences of ventricular tachycardia (VT) and ventricular fibrillation (VF) in the reperfusion period. The malondialdehyde content and xanthine oxidase activity were also decreased in global ischemic-reperfused hearts pretreated with THB (P < 0.01, or P < 0.05). It suggested that THB could protect the myocardium from ischemic and reperfusion injury. UR - http://www.chinaphar.com/article/view/8722